Particularly Hazardous Substances
Revised January 2022
Carcinogens – OSHA, IARC Group 1 and NTP Type 1
- 2-Acetylaminofluorene
- Acrylonitrile
- Aflatoxins
- 4-Aminobiphenyl
- Arsenic (and As compounds)
- Asbestos
- Azathioprine
- Benzene
- Benzidine
- Beryllium (and Be compounds)
- Bis(chloromethyl)ether
- 1,3-Butadiene
- 1,4-Butanediol dimethylsulfonate (myleran)
- Cadmium (and Cd compounds)
- Chlorambucil
- N,N-bis(2-Chloroethyl)-2-naphthylamine
- 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
- Chloromethylmethyl ether
- Chromium (VI) compounds
- Ciclosporin Coal tars (and volatiles and extracts)
- Cyclophosphamide
- 1,2-Dibromo-3-chloroproprane
- 3,3’-Dichlorobenzidine (and its salts)
- Diethylstilbestrol
- 4-Dimethylaminoazobenzene
- N,N-Dimethylnitrosoamine
- Erionite
- Estrogens (conjugated)
- Ethylene oxide
- Ethylenimine
- Formaldehyde
- Melphalan
- 8-Methoxypsoralen plus UV radiation
- Methylchloromethylether
- 4,4’-Methylenedianiline
- Mineral Oils (untreated and mildly treated)
- Mustard gas (bis(2-chloroethyl)sulfide)
- α-Naphthylamine
- β-Naphthylamine
- Nickel (and Ni compounds)
- 4-Nitrobiphenyl
- N-Nitrosodimethylamine
- Oestrogens (steroidal and non-steroidal)
- Oral contraceptives (combined and sequential)
- Phenacetin contained in analgesic mixtures
- β-Propiolactone
- Radon
- Shale Oils
- Silica (crystalline)
- Soots (containing PAHs)
- Tamoxifen
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin
- Thiotepa
- Thorium dioxide
- Tobacco Smoke (and smokeless tobacco)
- Treosulfan
- Vinyl Chloride
- Wood Dust (certain hard woods)
Examples of Reproductive Toxins – not all inclusive
- Arsenic (and certain arsenic compounds)
- Benzene
- Cadmium (and certain cadmium compounds)
- Carbon disulfide
- Ethylene glycol monomethyl and ethyl ethers
- Ethylene oxide
- Lead compounds
- Mercury compounds
- Vinyl Chloride
- Xylene
Examples of Chemicals With High Acute Toxicity (– not all inclusive)
- Acrolein
- Arsine
- Chlorine
- Diazomethane
- Diborane (gas)
- Hydrogen cyanide
- Hydrogen fluoride
- Methyl fluorosulfonate
- Nickel carbonyl
- Nitrogen dioxide
- Osmium tetroxide
- Ozone
- Phosgene
- Sodium azide
- Sodium cyanide (and cyanide salts)