Particularly Hazardous Substances

Revised January 2025

Carcinogens – OSHA, IARC Group 1 and NTP Type 1

  • 2-Acetylaminofluorene
  • Acrylonitrile
  • Aflatoxins
  • 4-Aminobiphenyl
  • Arsenic (and arsenic compounds)
  • Asbestos
  • Azathioprine
  • Benzene
  • Benzidine
  • Beryllium (and Be compounds)
  • Bis(chloromethyl)ether
  • 1,3-Butadiene
  • 1,4-Butanediol dimethylsulfonate (myleran)
  • Cadmium (and Cd compounds)
  • Chlorambucil
  • N,N-bis(2-Chloroethyl)-2-naphthylamine
  • 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
  • Chloromethylmethyl ether
  • Chromium (VI) compounds
  • Ciclosporin Coal tars (and volatiles and extracts)
  • Cyclophosphamide
  • 1,2-Dibromo-3-chloroproprane
  • 3,3’-Dichlorobenzidine (and its salts)
  • Diethylstilbestrol
  • 4-Dimethylaminoazobenzene
  • N,N-Dimethylnitrosoamine
  • Erionite
  • Estrogens (conjugated)
  • Ethylene oxide
  • Ethylenimine
  • Formaldehyde
  • Melphalan
  • 8-Methoxypsoralen plus UV radiation
  • Methylchloromethylether
  • 4,4’-Methylenedianiline
  • Mineral Oils (untreated and mildly treated)
  • Mustard gas (bis(2-chloroethyl)sulfide)
  • α-Naphthylamine
  • β-Naphthylamine
  • Nickel (and Ni compounds)
  • 4-Nitrobiphenyl
  • N-Nitrosodimethylamine
  • Oestrogens (steroidal and non-steroidal)
  • Oral contraceptives (combined and sequential)
  • Phenacetin contained in analgesic mixtures
  • β-Propiolactone
  • Radon
  • Shale Oils
  • Silica (crystalline)
  • Soots (containing PAHs)
  • Tamoxifen
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin
  • Thiotepa
  • Thorium dioxide
  • Tobacco Smoke (and smokeless tobacco)
  • Treosulfan
  • Vinyl Chloride
  • Wood Dust (certain hard woods)

Examples of Reproductive Toxins – not all inclusive

  • Arsenic (and certain arsenic compounds)
  • Benzene
  • Cadmium (and certain cadmium compounds)
  • Carbon disulfide
  • Ethylene glycol monomethyl and ethyl ethers
  • Ethylene oxide
  • Lead compounds
  • Mercury compounds
  • Vinyl Chloride
  • Xylene

Examples of Chemicals With High Acute Toxicity (– not all inclusive)

  • Acrolein
  • Arsine
  • Chlorine
  • Diazomethane
  • Diborane (gas)
  • Hydrogen cyanide
  • Hydrogen fluoride
  • Methyl fluorosulfonate
  • Nickel carbonyl
  • Nitrogen dioxide
  • Osmium tetroxide
  • Ozone
  • Phosgene
  • Sodium azide
  • Sodium cyanide (and cyanide salts)