Maryam Raeeszadeh-Sarmazdeh

Assistant Professor
Maryam Raeeszadeh-Sarmazdeh
Biography

Maryam Raeeszadeh-Sarmazdeh joined the University of Nevada, Reno in July 2019 as an assistant professor. Maryam was a senior research fellow in the Department of Cancer Biology at Mayo Clinic, Florida, during which her work was focused on engineering novel protein-based therapeutics based on natural enzyme inhibitors. Prior to her appointment at Mayo Clinic, she was a postdoctoral scholar at the Chemical and Biomolecular Engineering Department at the University of Delaware at Prof. Wilfred Chen's lab. Her research at University of Delaware was focused on enzyme and metabolic pathway engineering for generating biofuel. Maryam earned her Ph.D. in Chemical and Biomolecular Engineering from the University of Tennessee at Knoxville under Prof. Eric Boder's supervision. There, her research was focused on generating site-specific protein immobilization on the surface and protein engineering using yeast surface display and directed evolution.

Education
  • Ph.D., Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN, 2014
  • M.S., Chemical Engineering-Biotechnology, Sharif University of Technology, Tehran, Iran, 2008
  • B.S., Chemical Engineering, Sharif University of Technology, Tehran, Iran, 2005
Professional memberships
  • American Chemical Society (ACS)
  • American Institute of Chemical Engineers (AIChE)
  • American Society of Biochemistry and Molecular Biology(ASBMB)
  • Society of Biological Engineers (SBE)
  • Protein Society (PS)
  • Society of Women Engineers (SWE)

Prospective graduate students

There is an open position for a motivated graduate student who is interested in protein engineering to develop designer scaffolds and protein assemblies with applications in biomedicine, bioimaging, biomaterials, and biocatalysis. Prospective applicants should have a degree in chemical engineering, bioengineering, biochemistry and related fields. Applicants with skills and interest in protein engineering and design, including molecular biology, enzyme kinetics, protein biochemistry and structure, and cell-based assays are highly encouraged to apply for the position. Highly talented and motivated undergraduate students and visiting researchers are also welcome to our lab.

Interested applicants should email Dr. Raeeszadeh-Sarmazdeh at maryamr@unr.edu and include a CV outlining research interests and skills as wells as list of references.

Learn more about our graduate programs 

Research interests

  • Protein engineering
  • Directed evolution
  • Synthetic biology
  • Protein assembly
  • Enzymatic protein immobilization

Selected publications

  1. Maryam Raeeszadeh-Sarmazdeh, Kerrie Greene, Banumathi Sankaran, Derek C. Radisky, Evette S. Radisky, Directed Evolution of Metalloproteinase Inhibitor (TIMP-1) Reveals Cooperation Between Domains in Matrix Metalloproteinase Recognition, Journal of Biological Chemistry, 04/2019, 294(24) 9476 -9488
  2. Maryam Raeeszadeh-Sarmazdeh, Nikhil Patel, Sarah Cruise, Leila Owen, Hugh O'Neill, Eric T. Boder, Identifying Stable Fragments of Arabidopsis thaliana Cellulose Synthase Subunit 3 by Yeast Display, Biotechnology Journal, 09/2018; e1800353 (Front Cover).
  3. Evette S. Radisky, Maryam Raeeszadeh-Sarmazdeh, Derek C. Radisky: Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer. Journal of Cellular Biochemistry, 06/2017; 118(11):3531-3548.
  4. Maryam Raeeszadeh-Sarmazdeh, Ranganath Parthasarathy, Eric T. Boder: Fine-tuning Sortase-mediated Immobilization of Protein Layers on Surfaces using Sequential Deprotection and Coupling. Biotechnology Progress, 02/2017; 33(3): 824-83.
  5. Maryam Raeeszadeh-Sarmazdeh*, Emily Hartzell*, J. Vincent Price*, Wilfred Chen, Protein Nanoparticles as Multifunctional Biocatalysts and Health Assessment Sensors, invited review paper, Current Opinion in Chemical Engineering 08/2016; 13:109-118. (*: equal contribution)
  6. Heejae Kim, Ka‐Hei Siu, Maryam Raeeszadeh Sarmazdeh, Qing Sun, Qi Chen, Wilfred Chen: Bioengineering Strategies to Generate Artificial Protein Complexes. Biotechnology and Bioengineering 05/2015; 112(8).
  7. Maryam Raeeszadeh-Sarmazdeh, Ranganath Parthasarathy, Eric T. Boder: Site-specific Immobilization of Protein Layers on Gold Surfaces via Orthogonal Sortases. Colloids and surfaces B: Biointerfaces 04/2015; 128:457-63.
  8. Rosemary K. Le, Maryam Raeeszadeh-Sarmazdeh, Eric T. Boder, Paul D. Frymier: Sortase-Mediated Ligation of PsaE-Modified Photosystem I from Synechocystis sp. PCC 6803 to a Conductive Surface for Enhanced Photocurrent Production on a Gold Electrode. Langmuir 12/2014; 31(3).
  9. Eric T. Boder, Maryam Raeeszadeh-Sarmazdeh, J Vincent Price: Engineering Antibodies by Yeast Display. Archives of Biochemistry and Biophysics 03/2012; 526(2):99-106.