Alexander van der Linden, Ph.D.
- M.Sc, 1999, Molecular Biology, Leiden University, Netherlands
- Ph.D., 2003, Biology, Utrecht University, Netherlands
- Postdoc, 2009, Neurobiology, Brandeis University, Waltham
Understanding the underlying mechanisms by which internal and environmental signals affect an animal's behavior and development is a fundamental question in neurobiology. What are the molecules, pathways and neuronal circuits that allow animals to respond to internal and external signals? To study these questions, we use various molecular genetic and genomic tools in C. elegans.
Current projects in the lab are aimed at understanding three broad biological questions: 1) how do animals alter their behavior to an ever-changing environment? 2) how does the brain controls growth and fat metabolism? and 3) how does temperature regulate the circadian clock?
- Van der Linden, A.M., Beverley, M., Kadener, S., Rodriguez, J., Wasserman, S., Rosbash, M. and Sengupta, P. (2010) Genome-wide analysis of light and temperature-entrained circadian transcripts in C. elegans. PloS Biol. Oct 12;8(10):e1000503
- Van der Linden, A.M., Wiener S., You Y., Kim K., Avery L., and Sengupta, P. (2008) The EGL-4 PKG acts with the KIN-29 SIK and PKA to regulate chemoreceptor gene expression and sensory behaviors in C. elegans. Genetics Nov; 180(3): 1475-91.
- Van der Linden, A.M., Nolan, K.M., and Sengupta, P. (2007) KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC. EMBO J. 26(2): 358-70.
- Van der Linden, A.M. and Plasterk, R.H.A. (2004) Shotgun cloning of transposon insertions in the genome of Caenorhabditis elegans. Comp Funct Genomics 5(3): 225-29.
- Simmer, F.*, Moorman, C.*, Van der Linden, A.M.*, Kuijk, E., van den Berghe, P.V., Kamath, R., Fraser, A.G., Ahringer, J., and Plasterk, R.H.A. (2003). Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol. 1: 77-84. * authors contributed equally
- Van der Linden, A.M., Moorman, C., Cuppen, E., Korswagen, H.C. and Plasterk, R.H.A. (2003) Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C. Current Biology 13: 516-521.
- Van der Linden, A.M., Simmer, F., Cuppen, E., and Plasterk, R.H.A. (2001) The G-protein ß-subunit GPB-2 in Caenorhabditis elegans Regulates the Goa-Gqa Signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16. Genetics 158: 221-235.
- BIOL 190: Introduction to Cell and Molecular Biology
- BIOL 395: Laboratory in Genetics and Cell Biology
- BIOL 475 and 675: Neurobiology
- BIOL 479: Techniques in Neuroscience Laboratory
- BIOL 477 and 677: Genes, Brain & Behavior