Bob Ryan

Professor & Department Chair

Office: 775-682-7332
Fax: 775-784-1419
Email: robertryan@unr.edu
Building: HMS
Room: 146a
Mailstop: 330

Summary

Heart disease is a major cause of mortality in North America. While it is clear that development of cardiovascular disease is a multi-factorial process, it is evident that aberrations in lipid metabolism represent a significant risk factor. It is widely accepted that exchangeable apolipoproteins function in regulation of plasma lipid levels, yet the molecular basis for this role is not fully understood. Increased knowledge of the properties of exchangeable apolipoproteins will be useful in the development of therapeutic strategies to influence plasma lipid levels and thereby, reduce the risk of cardiovascular disease. Furthermore, by understanding the molecular basis of apolipoprotein function in lipid transport and metabolism, it should be possible to design strategies to enhance or interfere with biological processes dependent upon their action. Knowledge gained has direct relevance to the treatment of dyslipidemias, including hypercholesterolemia and disorders of lipid metabolism that affect children and adults.

Education

B.S. University of Nevada, 1977
Ph.D. University of Nevada, 1982

Publications

Journals

Cardiac-specific deficiency of 3-hydroxy-3-methylglutaryl coenzyme A lyase in mice causes cardiomyopathy and a distinct pattern of acyl-coenzyme A-related biomarkers.

2022

Mol. Genet. Metab. 137, 257-264. PMID: 36228350

Yang, H., Wang, Y., Tang, M-C., Waters, P., Wang, S., Allard, P., Ryan, R.O., Nuyt, A-M., Paradis, P., Schiffrin, E.L., Furtos, A. and Mitchell, G.A.

Cardiolipin nanodisks confer protection against doxorubicin-induced mitochondrial dysfunction.

2022

BBA Biomembranes.1864, 183984; DOI: 10.1016/j.bbamem.2022.183984. PMID: 35724738

Fox, C.A., Romenskaia, I. Dagda, R.K. and Ryan, R.O.

Diversion of acetyl CoA to 3-methylglutaconic acid caused by discrete inborn errors of metabolism.

2022

Metabolites, 12, 377. PMCID: PMC9146172

Jones, D.E., Jennings, E.A. and Ryan, R.O.

Foam fractionation of a recombinant biosurfactant apolipoprotein.

2022

J. Biotechnol. 343, 25-31. PMCID: PMC8714704.

Lethcoe, K., Fox, C.A. and Ryan, R.O.

Lutein nanodisks protect retinal pigment epithelial cells from UV light induced damage.

2022

Front. Nanotechnol. 4:955022. PMCID: PMC9851610. doi: 10.3389/fnano.2022.955022

Moschetti, A., Fox, C.A., McGowen, S. and Ryan, R.O.

Role of non-enzymatic chemical reactions in 3-methylglutaconic aciduria

2022

FEBS J. 289, 2948-2958. PMCID: PMC9117401

Jones, D.E., Romenskaia, I., Kosma, D.K. and Ryan R.O.

Studies of the cardiolipin interactome.

2022

Prog. Lipid Res. 88, 101195 PMID: 36202313.

Fox, C.A. and Ryan, R.O.

Calcium-induced release of cytochrome c from cardiolipin nanodisks: implications for apoptosis

2021

BBA Biomembranes, 1863, 183722. PMCID: PMC8464532

Fox, C.A., Lethcoe, K., and Ryan, R.O.

Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes.

2021

Nanomedicine NBM, 37, 102439. PMCID: PMC8464493

Moschetti, A, Dagda, R.K. and Ryan, R.O.

Inborn errors of metabolism associated with 3-methylglutaconic aciduria.

2021

Clin. Chim. Acta. 522, 96-104. PMCID: PMC8464523

Jones, D.E., Klacking, E. and Ryan R.O.

Isomerization of 3-methylglutaconic acid.

2021

JIMD Reports, 58, 61-69. PMCID: PMC7932859

Jones, D.E., Ricker, J.D., Geary, L.M., Kosma, D.K. and Ryan R.O.

Reconstituted HDL as a therapeutic delivery device.

2021

BBA Mol. Cell Biol. Lipids, 1866, 159025. PMCID: PMC9336189

Fox, C.A., Moschetti, A. and Ryan R.O.

trans-3-methylglutaconyl CoA isomerization-dependent protein acylation.

2021

Biochem. Biophys. Res. Commun. 534, 261-265. PMCID: PMC7785636

Young, R., Jones, D.E., Diacovich, L., Witkowski, A. and Ryan, R.O.

3-methylglutaric acid in mitochondrial energy metabolism.

2020

Clin. Chim. Acta. 502, 233-239. PMCID: PMC6994337

Jones, D.E., Perez, L. and Ryan, R.O.

Dye binding assay reveals doxorubicin preference for DNA versus cardiolipin

2020

Anal. Biochem. 594, 113617. PMCID: PMC7058507

Fox, C.A. and Ryan R.O.

Isomerization of trans-3-methylglutaconic acid

2020

JIMD Reports. 2020;1-9

Dylan E. Jones, J. David Ricker, Laina M. Geary, Dylan K. Kosma, Robert O. Ryan

Effect of curcumin on amyloid-like aggregates generated from methionine-oxidized apolipoprotein A-I.

2018

FEBS Open Bio. 2018 Jan 10;8(2):302-310.

Krishnamo01thy A, Tavoosi N, Chan GKL, Liu J, Ren G, Cavigiolio G and Ryan RO

Evaluation of cardiolipin nanodisks as lipid replacement therapy for Barth syndrome. J Biomed Res. 32

2018

J Biomed Res. 32(2): 107–112.

Ikon N, Hsu FF, Shearer J, Forte TM, Ryan RO

Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway.

2018

Invest New Drugs. 36(5):743-754

Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD

Barth Syndrome: Connecting Cardiolipin to Cardiomyopathy.

2017

Lipids. 2017 Feb;52(2):99-108.

Ikon N, Ryan RO.

Cardiolipin and mitochondrial cristae organization.

2017

Biochim Biophys Acta. 2017 Jun;1859(6):1156-1163.

Ikon N, Ryan RO.

Apolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis.

2016

J Biomed Res. 2016 Mar;30(2):88-93.

Forte TM, Sharma V, Ryan RO

Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats.

2015

Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1;309(11):G918-25

Zhang LS, Sato H, Yang Q, Ryan RO, Wang DQ, Howles PN, Tso P.

Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism.

2015

Curr Drug Targets. 2015;16(12):1274-80. Review.

Forte TM, Ryan RO.

Metabolic annotation of 2-ethylhydracrylic acid.

2015

Clin Chim Acta. 2015 Aug 25;448:91-7

Ryan RO

Curcumin homing to the nucleolus: mechanism for initiation of an apoptotic program.

2014

J Nutr Biochem. 2014 Nov;25(11):1117-1123.

Ghosh M, Ryan RO.