Robert ryan

Bob Ryan

Professor & Department Chair

Summary

Heart disease is a major cause of mortality in North America. While it is clear that development of cardiovascular disease is a multi-factorial process, it is evident that aberrations in lipid metabolism represent a significant risk factor. It is widely accepted that exchangeable apolipoproteins function in regulation of plasma lipid levels, yet the molecular basis for this role is not fully understood. Increased knowledge of the properties of exchangeable apolipoproteins will be useful in the development of therapeutic strategies to influence plasma lipid levels and thereby, reduce the risk of cardiovascular disease. Furthermore, by understanding the molecular basis of apolipoprotein function in lipid transport and metabolism, it should be possible to design strategies to enhance or interfere with biological processes dependent upon their action. Knowledge gained has direct relevance to the treatment of dyslipidemias, including hypercholesterolemia and disorders of lipid metabolism that affect children and adults.

Education

B.S. University of Nevada, 1977
Ph.D. University of Nevada, 1982

Publications

Journals

Barth Syndrome: Connecting Cardiolipin to Cardiomyopathy.

2017

Lipids. 2017 Feb;52(2):99-108.

Ikon N, Ryan RO.

Cardiolipin and mitochondrial cristae organization.

2017

Biochim Biophys Acta. 2017 Jun;1859(6):1156-1163.

Ikon N, Ryan RO.

Apolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis.

2016

J Biomed Res. 2016 Mar;30(2):88-93.

Forte TM, Sharma V, Ryan RO

Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats.

2015

Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1;309(11):G918-25

Zhang LS, Sato H, Yang Q, Ryan RO, Wang DQ, Howles PN, Tso P.

Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism.

2015

Curr Drug Targets. 2015;16(12):1274-80. Review.

Forte TM, Ryan RO.

Metabolic annotation of 2-ethylhydracrylic acid.

2015

Clin Chim Acta. 2015 Aug 25;448:91-7

Ryan RO

Curcumin homing to the nucleolus: mechanism for initiation of an apoptotic program.

2014

J Nutr Biochem. 2014 Nov;25(11):1117-1123.

Ghosh M, Ryan RO.