Robert ryan

Bob Ryan

Professor & Department Chair


Heart disease is a major cause of mortality in North America. While it is clear that development of cardiovascular disease is a multi-factorial process, it is evident that aberrations in lipid metabolism represent a significant risk factor. It is widely accepted that exchangeable apolipoproteins function in regulation of plasma lipid levels, yet the molecular basis for this role is not fully understood. Increased knowledge of the properties of exchangeable apolipoproteins will be useful in the development of therapeutic strategies to influence plasma lipid levels and thereby, reduce the risk of cardiovascular disease. Furthermore, by understanding the molecular basis of apolipoprotein function in lipid transport and metabolism, it should be possible to design strategies to enhance or interfere with biological processes dependent upon their action. Knowledge gained has direct relevance to the treatment of dyslipidemias, including hypercholesterolemia and disorders of lipid metabolism that affect children and adults.


B.S. University of Nevada, 1977
Ph.D. University of Nevada, 1982


Publications are listed below.


Cardiolipin nanodisks confer protection against doxorubicin-induced mitochondrial dysfunction.


BBA Biomembranes.1864, 183984; DOI: 10.1016/j.bbamem.2022.183984. PMID: 35724738

Fox, C.A., Romenskaia, I. Dagda, R.K. and Ryan, R.O.

Diversion of acetyl CoA to 3-methylglutaconic acid caused by discrete inborn errors of metabolism.


Metabolites, 12, 377. PMCID: PMC9146172

Jones, D.E., Jennings, E.A. and Ryan, R.O.

Foam fractionation of a recombinant biosurfactant apolipoprotein.


J. Biotechnol. 343, 25-31. PMCID: PMC8714704.

Lethcoe, K., Fox, C.A. and Ryan, R.O.

Lutein nanodisks protect retinal pigment epithelial cells from UV light induced damage.


Front. Nanotechnol. 4:955022. PMCID: PMC9851610. doi: 10.3389/fnano.2022.955022

Moschetti, A., Fox, C.A., McGowen, S. and Ryan, R.O.

Role of non-enzymatic chemical reactions in 3-methylglutaconic aciduria


FEBS J. 289, 2948-2958. PMCID: PMC9117401

Jones, D.E., Romenskaia, I., Kosma, D.K. and Ryan R.O.

Calcium-induced release of cytochrome c from cardiolipin nanodisks: implications for apoptosis


BBA Biomembranes, 1863, 183722. PMCID: PMC8464532

Fox, C.A., Lethcoe, K., and Ryan, R.O.

Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes.


Nanomedicine NBM, 37, 102439. PMCID: PMC8464493

Moschetti, A, Dagda, R.K. and Ryan, R.O.

Inborn errors of metabolism associated with 3-methylglutaconic aciduria.


Clin. Chim. Acta. 522, 96-104. PMCID: PMC8464523

Jones, D.E., Klacking, E. and Ryan R.O.

Isomerization of 3-methylglutaconic acid.


JIMD Reports, 58, 61-69. PMCID: PMC7932859

Jones, D.E., Ricker, J.D., Geary, L.M., Kosma, D.K. and Ryan R.O.

Reconstituted HDL as a therapeutic delivery device.


BBA Mol. Cell Biol. Lipids, 1866, 159025. PMCID: PMC9336189

Fox, C.A., Moschetti, A. and Ryan R.O.

trans-3-methylglutaconyl CoA isomerization-dependent protein acylation.


Biochem. Biophys. Res. Commun. 534, 261-265. PMCID: PMC7785636

Young, R., Jones, D.E., Diacovich, L., Witkowski, A. and Ryan, R.O.

Barth Syndrome: Connecting Cardiolipin to Cardiomyopathy.


Lipids. 2017 Feb;52(2):99-108.

Ikon N, Ryan RO.

Cardiolipin and mitochondrial cristae organization.


Biochim Biophys Acta. 2017 Jun;1859(6):1156-1163.

Ikon N, Ryan RO.

Apolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis.


J Biomed Res. 2016 Mar;30(2):88-93.

Forte TM, Sharma V, Ryan RO

Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats.


Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1;309(11):G918-25

Zhang LS, Sato H, Yang Q, Ryan RO, Wang DQ, Howles PN, Tso P.

Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism.


Curr Drug Targets. 2015;16(12):1274-80. Review.

Forte TM, Ryan RO.

Metabolic annotation of 2-ethylhydracrylic acid.


Clin Chim Acta. 2015 Aug 25;448:91-7

Ryan RO

Curcumin homing to the nucleolus: mechanism for initiation of an apoptotic program.


J Nutr Biochem. 2014 Nov;25(11):1117-1123.

Ghosh M, Ryan RO.