claudia rueckert

Claudia Rückert

Assistant Professor she/her


Arthropod-borne viruses (arboviruses) present a constant threat to public health across all continents except Antarctica. The global incidence is increasing due to climate change and globalization. The recent outbreaks of Zika virus and chikungunya virus across large parts of the Americas are examples for arbovirus emergence and re-emergence. However, some arboviruses, such as West Nile virus or California encephalitis virus, also present a threat to the health of U.S. residents, including those of the state of Nevada.

Our research program focuses on the interactions of these arboviruses with their mosquito (or tick) vector. Specifically, we study the antiviral responses of mosquitoes.  Our ultimate aim is to increase our understanding of virus-vector interactions to identify novel methods and targets for the control of arbovirus transmission.


  • BS Biology, University of Heidelberg, Germany, 2008
  • MS Molecular Biosciences, University of Heidelberg, Germany, 2010
  • PhD Virology, University of Edinburgh, UK, 2014



Arbovirus co-infection and co-transmission: a neglected public health concern? Unsolved Mystery


PLoS Biology.

C. B. F. Vogels, C. Rückert, S. M. Cavany, T. A. Perkins, G. D. Ebel, N. D. Grubaugh

Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses



K. S. Carpentier, B. J. Davenport, K. C. Haist, M. K. McCarthy, N. A. May, A. Robison, C. Rückert, G. D. Ebel, and T. E. Morrison.

Profiling of small RNA responses of Culex cells and mosquitoes during acute and persistent virus infection.


Insect Biochemistry and Molecular Biology. 2019;

C. Rückert, A. N. Prasad, A. Robison, N. D. Grubaugh, J. Weger-Lucarelli, G. D. Ebel

Adventitious viruses persistently infect three commonly used mosquito cell lines.


Virology. 2018;

J. Weger-Lucarelli, C. Rückert, N. D. Grubaugh, M. J. Misencik, P. M. Armstrong, M. D. Stenglein, G. D. Ebel, D. Brackney.

How do virus-mosquito interactions lead to viral emergence?


Trends in Parasitology. 2018;

C. Rückert, G. D. Ebel

Impact of simultaneous exposure to arboviruses on infection and transmission by Aedes aegypti mosquitoes.


Nature Communications. 2017;

C. Rückert, J. Weger-Lucarelli, S. M. Garcia-Luna, M. C. Young, A. D. Byas, R.A. Murrieta, J. R. Fauver, G. D. Ebel

Variation in competence for ZIKV transmission by Aedes aegypti and Aedes albopictus is dependent on salivary gland infection and escape barriers.


PLoS NTD. 2018;

S. M. Garcia-Luna, J. Weger-Lucarelli, C. Rückert, R. A Murrieta, M. C. Young, A. D. Byas, J. R. Fauver, R. Perera, A. E. Flores-Suarez, G. Ponce-Garcia, A. D. Rodriguez, G. D. Ebel, W. C. Black IV

Mosquitoes transmit unique West Nile virus populations during each feeding episode.


Cell Reports. 2017;

N. D. Grubaugh, J. R. Fauver, C. Rückert, J. Weger-Lucarelli, S. Garcia-Luna, R. A. Murrieta, A. Gendernalik, D. R. Smith, D. E. Brackney, G. D. Ebel

The influence of genetic bottlenecks, RNA interference-mediated diversification, and selective constraint on the evolution of a tick-borne virus.


Virus evolution.

N. D. Grubaugh, C. Rückert, P. M. Armstrong, A. Bransfield, J. Anderson, G. D. Ebel, D. E. Brackney

Antiviral responses of arthropod vectors: an update on recent advances’ Review article,



C. Rückert, L. Bell-Sakyi, J. K. Fazakerley & R. Fragkoudis

Co-infection of tick cell lines affects replication of intracellular bacterial and viral pathogens


Ticks and Tick-borne Diseases;

A. Moniuszko, C. Rückert, M. P. Alberdi, G. Barry, B. Stevenson, J. K. Fazakerley, A. Kohl & L. Bell-Sakyi