stan omaye

Stan Omaye



Nutrition & Aging: Efficacy of antioxidant compounds on atherosclerosis and the oxidation of low-density lipoproteins.

The incidence of cardiovascular diseases (CVD) increases markedly with age and is the largest contributor to morbidity and premature mortality in men and women. Increased levels of low-density lipoprotein (LDL) and free-radical mediated or oxidative damage of LDL represent a key risk factor and a key step in the pathogenesis of atherosclerosis. Therefore, LDL oxidation and CVD are closely linked and likely contribute to adverse health consequences and death in the elderly. We have been interested in attenuating the risk of CVD by dietary or supplemental antioxidants and have tested the ability of antioxidant levels and combinations to protect LDL isolated from human blood from oxidation. 

Environmental Health: Health effects of air pollutants, environmental tobacco smoke, mercury contamination in Northern Nevada

A multi-disciplinary approach has been used to investigate potential links between health effects and various environmental pollutants. Past or ongoing projects include:

  1. Impact of regulatory changes on air pollution and health in Northern Nevada;
  2. Maternal, neonate and environmental tobacco smoke;
  3. Assessing community needs in environmental health; and
  4. Mercury and health effects in Northern Nevada. 

Health Promoting Bioactive Compounds: Selected phytochemicals and conjugated linoleic acid.

There are a variety of chemicals derived from plant and animal tissue that have the potential for promoting health, when consumed. Nutraceuticals is the term coined for such bioactive compounds, i.e., chemicals found as a natural component of foods or other ingestible forms that have been determined to be beneficial to the human body in preventing or treating one or more diseases. For over a decade, we have been interested in several of such chemicals and are continuing our efforts to understand their mode of action. Many of these compounds have antioxidant properties, thus we have focused on developing a better understanding about how they impact on oxidative stress using test tube models, animal studies, and human trials. 

Improving Food Safety for Vulnerable Populations of Nevada

Preventing foodborne illness and death remains a major public health challenge and substantially reducing foodborne disease outbreaks is a goal of Healthy People 2010. CDC still estimates that 76 million people get sick, more than 300,000 are hospitalized and approximately 5,000 Americans die each year from foodborne illnesses. Those at risk are the elderly, pregnant women, infants, and young children and those with compromised immune system. Thus, one in every five individuals in the U.S. falls into one of these as-risk categories. Because of Nevada’s growing elderly and young populations and the economic dependency on food service related tourism, we are particularly vulnerable. We are involved in assisting these vulnerable populations through food safety research and education. 

Nutritional Quality of Foods Grown by Urban Systems

Research studying the effects of growing conditions on production of bioactive compounds.  Using subjective methods, we are comparing sensory quality of produce grown in traditional soil to those grown hydroponically. We also are interested in the effects of environmental stresses on the level of production of bioactive compounds. We will determine the effects of such stresses on the quality of produce.


B.A., Chemistry, California State University, Sacramento, CA
M.S., Pharmacology, University of the Pacific, Stockton, CA
Ph.D., Nutrition, University of California, Davis, CA


Book Chapter(s)

The proof of fruits and vegetables grown hydroponically is in the eating: Sensory attributes of hydroponic grown fruits and vegetables.


In Md. Asaduzzaman (Ed.), Controlled Environment Agriculture – Production of Specialty Crops providing Human Health Benefits Through Hydroponics. (pp. 175-196). Hauppauge, NY

Treftz, C., Omaye, S. T.

Grape wine and tea polyphenolics in the modulation of atherosclerosis and heart disease.


Nutraceutical Handbook, 2nd edition (Wildmann, R., Ed.) CRC Press

Dubick, M. A., and Omaye, S. T.

Maternal environmental tobacco exposure and in utero and adverse birth outcomes.


Inhalation Toxicology, 2nd edition, Salem, H. and Katz, S. A., Eds., pp, 875-912, CRC Press, Roco Ratan, FL.

Todd, S. J. T. and Omaye, S. T.

Food and Nutritional Toxicology


CRC Press

Omaye, S. T.


Conjugated linoleic acid (CLA)-mediated gene expression and implications for atherosclerosis.


International Atherosclerosis Society (IAS) commentaries. March 16, 2009.

Nakamura, Y. K., and Omaye, S. T.

Vitamin E-modulated ROS generation and ROS-related diseases.


International Atherosclerosis Society (IAS) commentaries. October 5, 2009.

Nakamura, Y. K., and Omaye, S. T.

Fact Sheets

Hydroponics: A Brief Guide to Growing Food Without Soil


Extension | University of Nevada, Reno, Fact Sheet FS-15-08

Treftz, C., Kratsch, H., and Omaye, S.

Hydroponics comes from the Greek word “hydro,” meaning water, and “ponos,” meaning labor. In other words, hydroponics is gardening without soil. Growing food in a desert can be difficult because of...


Antioxidants: Looking Forward After a Decad.


Antioxidants, 10(12), 1992

Omaye, S. T.

Comparison between Hydroponic- and Soil-Grown Raspberries (Rubus idaeus): Viability and Sensory Traits.


Food and Nutrition Sciences., 6, 1533-1540.

Treftz, C., Omaye, S. T.

Vitamin and trace element loss from negative pressure wound therapy.


Advances in Skin & Wound Care.

Hourigan, L. A., Omaye, S. T., Keen, C. L., Jones, J. A., Dubick, M. A.

Comparative study of ascorbic acid and tocopherol concentrations in hydroponic- and soil-grown lettuces.


Food and Nutrition Sciences, 4, 1047-1053.

Buchanan, D. N., Omaye, S. T.

Antioxidants to supplement or not to supplement that is the question.


Antioxidants, 1, 1-3.

Omaye, S. T., Elsayed, N.

Gamma-glutamylcysteine inhibits oxidative stress in human endothelial cells.


Life Sciences, 90, 116-121.

Nakamura, Y. K., Dubick, M. A., Omaye, S. T.

Metabolic diseases and pro- and prebiotics: Mechanistic insights


Nutrition & Metabolism, 9, 1-9.

Nakamura, Y. K., Omaye, S. T.

Metabolic diseases and pro- and prebiotics: mechanistic insights


Nutrition & Metabolism 9: 60-72.

Nakamura, Y.K., and Omaye, S. T.

Lipophilic compound-mediated gene expression and implication for intervention in reactive oxygen species (ROS)-related diseases.


Nutrients, 2, 725-736

Nakamura, Y. K., Omaye, S. T.

Safety of vitamins and minerals: Controversies and perspective.


Toxicological Sciences, 118(2), 348-355

Soni, M. G., Thurmond, T. S., Miller, E. R., Spriggs, T., Bendich, A., Omaye, S. T.

Air pollutants, oxidative stress and human health.


Mutation Research/Genetic Toxicology and Environmental Mutagenesis 674:45-54.

Yang, W., and Omaye, S. T.

Conjugated linoleic acid isomers’ roles in the regulation of PPARgamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical endothelial cells.


Nutrition 25: 800-811.

Nakamura, Y. K., and Omaye, S. T.

Food safety behaviors of adult/elderly caregivers in Nevada.


J Food Safety 29: 163-175

Wilson, M., Surrendera-Babu, A., Omaye, S. T.

Survey of Food Safety Behaviour in Nevada Child Caregivers


International Journal of Food Safety, Nutrition and Public Health 2: Publication), 1: 116-126

Wilson, M., Surrendera-Babu, A., Omaye, S. T.

Vitamin E-modulated gene expression associated with ROS generation.


J Functional Foods 1:241-252.

Nakamura, Y. K. and Omaye, S. T.

alpha-Tocopherol modulation of human umbilical vein endothelial cell expression of Cu/Zn superoxide and catalase and lipid peroxidation through alteration of PPARgamma and NF-kappaB DNA binding activities.


Nutr Res 28: 671-680

Nakamura, Y. K., and Omaye, S. T.

Concentration dependent antioxidant activities of conjugated linoleic acid and alpha-tocopherol in corn oil


Journal of the Science of Food and Agriculture 87: 2715 —2720

badr El-Din, N. K. and Omaye, S. T.

Additive or synergetic effects of phenolic compounds on human low density lipoprotein oxidation.


Food Chem Toxicol 44: 510-516.

Cirico, T. L., and Omaye, S. T.

Oxidation of serum low-density lipoprotein and antioxidant status in young and elderly humans.


Arch Gerotol Geriatrics 42: 265-276.

Nakamura, Y. K., Read, M. H., Elias, J. W., and Omaye, S. T.

Special Publications

Nutritional and Sensory Analysis of Raspberry Varieties Grown in Northern Nevada


University of Nevada Cooperative Extension, Special Publication 16-14

Jacobs, J., Kratsch, H., Omaye, S., and Treftz C.

The purpose of this study was to measure vitamin C, vitamin E, total polyphenolics (antioxidants) and sugars (glucose and fructose) in several raspberry varieties during two growing seasons and during...