Yumei Feng Earley, Ph.D.

Associate Professor
Yumei Feng

Contact Information

Degrees

  • Ph.D., Molecular Pharmacology, Chongqing Medical University, China, 2005
  • M.D., Clinical Medicine, Zhejiang Medical University, China, 1995

Academic and Professional Positions

  • 2016-present Associate Professor, Department of Pharmacology and Physiology & Cell Biology, University of Nevada, Reno, School of Medicine, Reno, NV
  • 2015-2016 Assistant Professor, Department of Pharmacology and Physiology & Cell Biology, University of Nevada, Reno, School of Medicine, Reno, NV
  • 2013-2015 Adjunct Assistant Professor, Department of Physiology, Tulane University School of Medicine, New Orleans, LA.
  • 2013-2015 Assistant Professor, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO.
  • 2010-2013 Assistant Professor of Physiology, Tulane University School of Medicine, New Orleans, LA.
  • 2010-2013 Director, Mouse Phenotyping Core, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA.
  • 2006-2010 Postdoctoral Researcher, Louisiana State University Health Sciences Center, New Orleans (Mentor: Dr. Eric Lazartigues).
  • 2005-2006 Research Scientist, Vaccine and Biomedicine Center, Guangzhou, Institute of Biomedicine and Health, Chinese Academy of Sciences.
  • 1995-2000 Physician, Department of Internal Medicine, Changshan People's Hospital, Zhejiang Province, P.R. China.

Faculty member within the following departments and programs:

Research Interests

The current focus of my laboratory is to understand the neural mechanisms of hypertension and other cardiovascular diseases including diabetes and obesity. Our current interest is focused on the physiological and pathophysiological role of the (pro)renin receptor (PRR) and prorenin as a novel pathway for brain renin-angiotensin system. Briefly, we are interested in dissecting the importance of PRR in neurons, astrocyte, and microglial cells in mediating angiotensin II formation, and the neural circuits involved in hypertension with special focus on the subfornical organ (SFO) and the paraventricular nucleus of hypothalamus (PVN).

To achieve our goal, we have developed a PRR conditional knockout mouse (Cre-Loxp strategy) model and a neuron-targeted human PRR transgenic mouse model. We have also developed adeno-associated virus coding for PRR or PRR-shRNA to specifically target brain nuclei. Expertise in our laboratory includes but not limited to blood pressure, heart rate recording in conscious free moving mice using telemetry system; brain nuclei-targeted microinjection; sympathetic nerve activity recording and autonomic function assessment; as well as routine cell and molecular biology techniques. These powerful tools allow us to dissect the neural mechanisms and signaling pathways of brain PRR and renin-angiotensin system in neurogenic hypertension, diabetes, and obesity.

Current Projects

  • To investigate the critical role and neural mechanisms of (pro)renin receptor activation in the development of salt-sensitive hypertension in the central nervous system.
  • Elucidate the contribution of (pro)renin receptor-mediated MAPK signaling in the paraventricular nucleus of hypothalamus to the development and maintenance of hypertension.
  • Epigenetic regulation of brain (pro)renin receptor in salt-sensitive hypertension.
  • Develop and characterize (pro)renin receptor antagonist for the treatment of resistant hypertension and other cardiovascular diseases.
  • Novel neural mechanisms of resistant hypertension.

2018

  • Trebak F, Li, W, and Feng Y. The neuronal (pro)renin receptor regulates deoxycorticosterone-induced sodium intake. Physiol Genomics, doi: 10.1152/physiolgenomics.00065, 2018. PMID: 301420282018
  • Cooper SG, Trivedi DP, Yamamoto R, Worker CJ, Feng CY, Sorensen JT, Yang W, Xiong Z, and Feng Y. 2018. Increased (pro)renin receptor in subfornical organ neurons in hypertensive humans. Am J Physiol Heart Circ Physiol, 314: H796-H804, 2018. PMCID: 5966774.
  • Romanick S, Ulrich C, Schlauch K, Hostler A, Payne J, Woolsey R, Quilici D, Feng Y, and Ferguson B. 2018. Obesity-mediated regulation of cardiac protein acetylation: Parallel analysis of total and acetylated protein via TMT-tagged mass spectrometry. Bioscience Reports, July 30. Doi: 10.1042/BSR20180721, 2018. PMID: 30061171.
  • Peng H, Jensen DD, Li W, Sullivan MN, Buller SA, Worker CJ, Cooper SG, Zheng S, Earley S, Sigmund CD, and Feng Y. 2018. Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system. Am J Physiol Heart Circ Physiol, 314: H580-H592, 2018. PMCID: 5899258.

2016

  • Xu Q, Jensen DD, Peng H, and Feng Y. 2016. The Critical role of the central nervous system (pro)renin receptor in regulation of systemic blood pressure. Pharmacology & Therepeutics, 164: 126-134, 2016 (Review). PMCID: 4942374.
  • Pitra S, Feng Y, and Stern JE. 2016. Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control. Molecular Metabolism, 5: 858-868,2016.
  • Lu X, Wang F, Xu C, Soodvilai S, Peng K, Su J, Zhao L, Yang KT, Feng Y, Zhou S-F, Gustafsson J-A, and Yang T. 2016. Soluble (pro)renin receptor via β-catenin enhances urine concentration capability: a target of liver X receptor. Proceedings of the National Academy of Sciences, 113: E189-8-1906, 2016.

2015

  • Feng Y. 2015. Ang II-independent prorenin/(pro)renin receptor signaling pathways in the central nervous system. American Journal of Physiology: Heart and Circulatory Physiology. 309: H731-3, 2015 PMID: 26209058 (Review).
  • Li W, Liu J, Saifudeen Z, and Feng Y. 2015. Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein in DOCA-salt-induced hypertension. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 309: R138-147, 2015. PMID: 25994957.
  • Li W, Sullivan MN, Zhang S, Worker CJ, Xiong Z, Speth RC, and Feng Y. 2015. Intracerebroventricular infusion of the (pro)renin receptor antagonist PRO20 attenuates neurogenic hypertension. Hypertension, 65:352-361, 2015. PMID: 25421983.
  • Sullivan MN, Gonzales AL, Pires PW, Bruhl A, Leo MD, Li W, Oulidi A, Boop FA, Feng Y, Jaggar JH, Welsh DG, and Earley S. 2015. Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation. Science Signaling. 8: ra2, 2015. PMID: 25564678.
  • Li Y, Liu J, Li W, Brown A, Baddoo M, Li M, Carroll T, Oxburgh L, Feng Y, and Saifudeen Z. 2015. P53 enables metabolic fitness and self-renewal of nephron progenitor cells. Development, 142: 1228-1241, 2015. PMID: 25804735.
  • Wang F, Lu X, Liu M, Feng Y, Zhou S-F, and Yang T. 2015. Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of local renin-angiotensin system. BMC Medicine, 13: 278, 2015. PMID: 26554902.

2014

  • Zubcevic J, Jun JY, Kim S, Perez PD, Afzal A, Shan Z, Li W, Santisteban MM, Yuan W, Febo M, Mocco J, Feng Y, Scott E, Baekey DM, and Raizada MK. 2014. Altered inflammatory response is associated with an impaired autonomic input to the bone marrow in the SHR. Hypertension. 63: 542-50, 2014. PMID: 24366083.
  • Xia H, de Queiroz TM, Sriramula S, Feng Y, Johnson T, Mungrue IM, Lazartigues E. 2014. Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 308: R370-8, 2015. PMID: 25519733.
  • Cao T, Li W, Seth D, Navar G, and Feng Y. 2014. Brain-targeted (pro)renin receptor knockdown modulates body fluid homeostasis. Journal of Hypertension, 3: 160, DOI: 10.4172/2167-1095.1000160, 2014.
  • Li W, Peng H, Mehaffey EP, Kimball CD, Grobe JL, van Gool JMG, Danser AJH, Ichihara A, and Feng Y. 2014. Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertension. Hypertension. 63: 316-23, 2014. PMID: 24246383.

2013

  • Cao T and Feng Y. 2013. (Pro)renin receptor and body fluid homeostasis. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 305 (2): R104-6, 2013. PMID: 23678024 (Review).
  • Peng H, Li W, Seth DM, Nair AR, Francis J, and Feng Y. 2013. (Pro)renin receptor mediates both angiotensin II-dependent and -independent superoxide production in neuronal cells. PLoS One. 8 (3): e58339, 2013. PMID: 23516464.
  • Li W, Peng H, Seth DM, and Feng Y. 2013. The prorenin and (pro)renin receptor: new players in the brain renin-angiotensin system. International Journal of Hypertension. 2012: 290635. 2012. PMID: 23316344 (Review).

2012

  • Feng Y, Hans C, Mcllwain E, Varner KJ, and Lazartigues E. 2012. Angiotensin-converting enzyme 2 over-expression in the central nervous system reduces angiotensin-II-mediated cardiac hypertrophy. PLoS One.7: e48910, 2012. PMID: 23155428.
  • Li W, Peng H, Cao T, Sato R, McDaniels SJ, Kobori H, Navar LG, and Feng Y. 2012. Brain-targeted (pro)renin receptor knockdown attenuates angiotensin II-dependent hypertension. Hypertension. 59: 1188-1194, 2012. PMID: 22526255.

2011

  • Xia H, Suda S, Bindom SA, Feng Y, Gurley SB, Seth DM, Navar LG and Lazartigues E. 2011. ACE2-Mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. PLoS One. 6(7): e22682. 2011. PMID: 21818366.
  • Prieto MC, Gonzalez-Villalobos RA, Botros FT, Martin VL, Pagan J, Sato R, Lara LS, Feng Y, Fernandez F, Kobori H, Casarini DE, and Navar LG. 2011. Reciprocal changes in renal ACE/Ang II and ACE2/Ang 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats. American Journal of Physiology - Renal Physiology. 300 (3): F749-55. 2011. PMID: 21209009.

2010

  • Feng Y, Xia H, Santos RA, Speth RC and Lazartigues E. 2010. ACE2: a new target for neurogenic hypertension. Experimental Physiology. 95(5): 601-6, 2010. (Selected for the Cover) PMID: 19923158.
  • Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD and Lazartigues E. 2010. Brain-selective over-expression of human Angiotensin Converting Enzyme 2 attenuates neurogenic hypertension. Circulation Research. 106:373-382; 2010. (Selected for the Cover) PMID: 19926873.
  • Hans C, Feng Y, Naura A, Troxclair D, Naura AS, Zerfaoui M, Ju J, Kaye AD, Lazartigues E, DeClerck YA, and Boulares AH. 2010. Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. Cardiovascular Pathology. 20(2): e56-68, 2010. PMID: 20434371.

2009

  • Xia H, Feng Y, Obr TD, Hickman PJ and Lazartigues E. 2009. AT1 receptor-mediated reduction of ACE2 activity in the brain impairs baroreflex function in hypertensive mice. Hypertension. 53(2):210-6; 2009. PMID: 19124678.
  • Hans C, Feng Y, Naura A, Zerfaoui M, Rezk B, Xia H, Kaye A, Matrougui K, Lazartigues E and Boulares H. 2009. Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE-/- mice: effects on eNOS and oxidative stress. PLoS One. 4(10): e7430; 2009. PMID: 19823587.
  • Zhang X, Wang G, Dupré DJ, Feng Y, Robitaille M, Lazartigues E, Feng YH, Hébert TE, and Wu G. 2009. Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor. Journal of Pharmacology and Experimental Therapeutics. 330(1):109-17; 2009. PMID: 19357319.
  • Xu W, Yi L, Feng Y, Chen L and Liu J. 2009. Structure insight into the activation mechanism of human pancreatic prophospholipase A2. The Journal of Biological Chemistry. 284: 16659-16666; 2009. PMID: 19297324.

2008

  • Feng Y, Yue X, Xia H, Bindom SA, Hickman PJ, Filipeanu C, Wu G and Lazartigues E. 2008. Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circulation Research. 102(6):729-36; 2008. PMID: 18258853.
  • Park S, Bivona BJ, Feng Y, Lazartigues E, and Harrison-Bernard LM. 2008. Intact renal afferent arteriolar autoregulatory responsiveness in db/db mice. American Journal of Physiology - Renal Physiology. 295:F1504-1511; 2008. PMID: 18753291.