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Nevada Transgenic Center

Phone(775) 784-4874
Address 1664 N. Virginia Street
Reno,  NV  89557
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Publications

Publications

  1. Boppart MD, Volker SE, Alexander NM, Burkin DJ and Kaufman SJ. Exercise Promotes {alpha}7 Integrin Gene Transcription and Protection of Skeletal Muscle. Am J Physiol Regul Integr Comp Physiol 2008.
  2. Boppart MD, Burkin DJ and Kaufman SJ. α7β1-Integrin Regulates Mechanotransduction and Prevents Skeletal Muscle Injury. Am J Physiol Cell Physiol 00317, 2006.
  3. Burkin DJ, Wallace GQ, Milner DJ, Chaney EJ, Mulligan JA and Kaufman SJ. Transgenic expression of {alpha}7{beta}1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice. Am J Pathol 166: 253-263, 2005.
  4. Chen H, Liu LL, Ye LL, McGuckin C, Tamowski S, Scowen P, Tian H, Murray K, Hatton WJ and Duan D. Targeted inactivation of cystic fibrosis transmembrane conductance regulator chloride channel gene prevents ischemic preconditioning in isolated mouse heart. Circulation 110: 700-704, 2004.
  5. Doe JA, Wuebbles RD, Allred ET, Rooney, JE and Burkin DJ. (2011). Transgenic overexpression of the alpha7 integrin reduces muscle pathology and improves viability in the dyW mouse model of MDC1A. Journal of Cell Science 124: 2287-2297.
  6. Flintoff-Dye NL, Welser J, Rooney J, Scowen P, Tamowski S, Hatton W and Burkin DJ. Role for the alpha7beta1 integrin in vascular development and integrity. Dev Dyn 234: 11-21, 2005.
  7. Gurpur PB, Liu J, Burkin DJ and Kaufman SJ. Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy. Am J Pathol 174: 999-1008, 2009.
  8. Jin J, Jin N, Zheng H, Ro S, Tafolla D, Sanders KM and Yan W. Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse. Biol Reprod 77: 37-44, 2007.
  9. Liu J, Burkin DJ and Kaufman SJ. Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression. Am J Physiol Cell Physiol 294: C627-C640, 2008.
  10. Rooney JE, Gurpur PB and Burkin DJ. Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy. Proc Natl Acad Sci U S A 106: 7991-7996, 2009.
  11. Rooney JE, Gurpur PB, Yablonka-Reuveni Z and Burkin DJ. Laminin-111 restores regenerative capacity in a mouse model for alpha7 integrin congenital myopathy. Am J Pathol 174: 256-264, 2009.
  12. Rooney JE, Knapp JR, Hodges, BL, Wuebbles RD and Burkin DJ (2012). Laminin-111 protein therapy reduces muscle pathology and improves viability of a mouse model of merosin-deficient congenital muscular dystrophy. AmeriJournal of Pathology 4:1593-1602can.
  13. Rooney JE, Welser JV, Dechert MA, Flintoff-Dye NL, Kaufman SJ and Burkin DJ. Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin. J Cell Sci 119: 2185-2195, 2006.
  14. Welser JV, Lange ND, Flintoff-Dye N, Burkin HR and Burkin DJ. Placental defects in alpha7 integrin null mice. Placenta 28: 1219-1228, 2007.
  15. Welser JV, Rooney JE, Cohen NC, Gurpur PB, Singer CA, Evans RA, Haines BA and Burkin DJ. Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin. Am J Pathol 175: 1545-1554, 2009.
  16. Welser JV, Lange N, Singer CA, Elorza M, Scowen P, Keef KD, Gerthoffer WT and Burkin DJ. Loss of the {alpha}7 Integrin Promotes Extracellular Signal-Regulated Kinase Activation and Altered Vascular Remodeling. Circ Res 101: 672-681, 2007.
  17. Xiong D, Heyman NS, Airey J, Zhang M, Singer CA, Rawat S, Ye L, Evans R, Burkin DJ, Tian H, McCloskey DT, Valencik M, Britton FC, Duan D and Hume JR. Cardiac-specific, inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice. J Mol Cell Cardiol 48: 211-219, 2010.
  18. Xiong D, Wang GX, Burkin DJ, Yamboliev IA, Singer CA, Rawat S, Scowen P, Evans R, Ye L, Hatton WJ, Tian H, Keller PS, McCloskey DT, Duan D and Hume JR. CARDIAC-SPECIFIC OVEREXPRESSION OF THE HUMAN SHORT CLC-3 CHLORIDE CHANNEL ISOFORM IN MICE. Clin Exp Pharmacol Physiol 2008.
  19. Yamamoto-Mizuma S, Wang GX and Hume JR. P2Y purinergic receptor regulation of CFTR chloride channels in mouse cardiac myocytes. J Physiol 556: 727-737, 2004.
  20. Yamamoto-Mizuma S, Wang GX, Liu LL, Schegg K, Hatton WJ, Duan D, Horowitz TL, Lamb FS and Hume JR. Altered properties of volume-sensitive osmolyte and anion channels (VSOACs) and membrane protein expression in cardiac and smooth muscle myocytes from Clcn3-/- mice. J Physiol 557: 439-456, 2004.

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University of Nevada, Reno

University of Nevada, Reno
1664 N. Virginia Street
Reno,  NV  89557-

(775) 784-1110
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