Most conference attendees will fly into Reno-Tahoe International Airport http://www.renoairport.com/
The conference hotel at the South Lake Tahoe location is roughly 60 miles and roughly a 90 minute drive from the Reno-Tahoe International Airport.
You may want to rent a car to have travel flexibility. If you want to rent a car, you can find rental car information on the airport website http://www.renoairport.com/tofrom-airport/rental-cars for companies leasing at the airport.
If you play to just enjoy the South Lake Tahoe area, you do not need to rent a car. A less expensive alternative to renting a car, that will enable you to get from the airport to the conference hotel and back, is the South Tahoe Express http://www.southtahoeexpress.com/ It provides shuttle service between Reno-Tahoe International Airport & South Lake Tahoe Resorts, including the Conference Hotel (Harveys). There are numerous daily departures each way. The current round trip cost is $53 per person for adults, or $29.75 one way.
An alternative to flying into Reno is flying into San Francisco and renting a car. This would provide you with the opportunity to see areas in California, and would provide travel flexibility. The drive from San Francisco to the conference hotel is about 202 miles, or about 5 hours in normal conditions. You can obtain on the San Francisco airport and its rental cars at http://www.flysfo.com/