Shinobu Kitayama, PhD
University of Michigan
Center for Japanese Studies and Department of Psychology
Cultural Neuroscience: Current Evidence and Future Prospect
3:00 pm, Friday, April 18th at MIKC Wells Fargo Auditorium
Cultural neuroscience is an emerging field that examines the interdependencies among culture, mind, and the brain. By investigating brain plasticity in varying social and ecological contexts, it seeks to overcome the nature-nurture dichotomy. In the present talk, after a brief overview of the field, I will illustrate its potential by reviewing evidence for cultural variations in brain mechanisms underlying cognition (i.e., holistic attention), emotion (i.e., emotion regulation), and motivation (i.e., self-serving bias). Directions for future research will be discussed.
Peter Tse, PhD
Department of Psychological & Brain Sciences
Chunking of visual features in space and time: Behavioral and neuronal mechanisms
4 pm, Monday, March 10, 2014 - DMS 104
We can learn arbitrary feature conjunctions when the to-be-combined features are present at the same time (Wang et al., 1994). This learning is underpinned by increased activity in visual cortex (Frank et al., 2013). I will discuss data that suggest that this kind of feature-conjunction perceptual learning requires attention, is not strongly retinotopic, and can even link features that do not appear at the same time.
Ioulia Kovelman, PhD
University of Michigan
Center for Human Growth & Development
Building a Vision: Shared Multimodal Pediatric fNIRS Brain Imaging Facility at the University of Michigan
4:00 pm, Tues, February 18 - MIKC 124 Wells Fargo Auditorium
Kovelman's research interests are in language and reading development in monolingual and bilingual infants, children, and adults. It includes both typical and atypical language and reading development using a variety of behavioral and brain imaging methods (fMRI, fNIRS).
David M. Raizen, MD, PhD
Assistant Professor of Neurology
University of Pennsylvania
Department of Neurology
Using the worm to catch Z's: somnogen discovery in C. elegans
11 am, Fri. February 7, 2014 - DMS 104
Quiescent behavioral states are universal to the animal world with the most famous and mysterious of these being sleep. Despite the fact that we spend one third of our life sleeping, and despite the fact that all animals appear to sleep, the core function of sleep remains a mystery. In addition, the molecular basis underlying sleep/wake regulation is poorly understood. Raizen uses C. elegans as a model system to address these questions. C. elegans offers many experimental advantages including powerful genetic tools as well as a simple neuroanatomy. Growth of C. elegans from an embryo to an adult is punctuated by four molts, during which the animal secretes a new cuticle and sheds its old one. Prior to each molt the worm has a quiescent behavioral state called lethargus. Lethargus has several similarities to sleep including rapid reversibility to strong stimulation, increased sensory arousal threshold, and homeostasis, which is manifested by an increased depth of sleep following a period of deprivation. Similarity to sleep at the molecular genetic level is demonstrated by the identification of signaling pathways that regulate C. elegans lethargus in the similar fashion to their regulation of sleep in mammals and arthropods. For examples, cAMP signaling promotes wakefulness and epidermal growth factor signaling promotes sleep in C. elegans and other organisms. The Raizen lab has identified new regulators of sleep like behavior in C. elegans and is currently studying how these regulators function to regulate sleep. By studying the purpose and genetic regulation of nematode lethargus, they hope to identify additional novel sleep regulators, and to gain insight into why sleep and sleep-like states had evolved, a central biological mystery.
Dragana Rogulja, PhD
Assistant Professor in Neurobiology
Harvard Medical School
Department of Neurobiology
Cell cycle genes repurposed as sleep factors
October 18, 2013, 11:00 am, Davidson Math and Science, Room 104
A remarkable change occurs in our brains each night, making us lose the essence of who we are for hours at a time: we fall asleep. A process so familiar to us, sleep nevertheless remains among the most mysterious phenomena in biology. The goal of our work is to understand how the brain reversibly switches between waking and sleep states, and why we need to sleep in the first place. To address these questions, Rogulja uses Drosophila melanogaster as a model system, because sleep in the fly is remarkably similar to mammalian sleep. Flies have consolidated periods of activity and sleep; arousal threshold is elevated in sleeping flies; the brain's electrical activity differs between sleeping and awake flies. As in people, both circadian and homeostatic mechanisms provide input into the regulation of fly sleep: flies are normally active during the day and quiescent at night, but if deprived of sleep will show a consequent increase in "rebound" sleep, regardless of the time of day.
Alison Harris, PhD
Claremont McKenna College
Department of Psychology
HD-EEG Analysis Workshop
October 18, 2013, 10 am, Neuroimaging Core, Mack Social Science 412
Event-related brain dynamics of value and decision-making
October 18, 2013, 3:30 pm, Ansari 101
From selecting a snack in the supermarket to allocating financial resources, our lives are filled with choices. Emerging research from human neuroimaging suggests that a common neural circuitry underlies such disparate decisions: in particular, the ventromedial prefrontal cortex (vmPFC) has been associated with subjective value across a wide variety of tasks and goods. However, due to the inherent limitations of hemodynamic measures, comparatively little is known about when and how the vmPFC computes value signals across the time course of decision. Harris will discuss research exploiting the high temporal resolution and whole-brain coverage of event-related potentials (ERP) in order to examine the dynamic construction of value signals. Combined with advanced statistical and source reconstruction techniques, this novel approach reveals that neural activity correlated with subjective preference emerges approximately 400 ms after stimulus onset, localized to regions including vmPFC. Reflecting the integration of sensory attribute information, activity in this time window is also modulated by top-down goals (e.g., weight loss) through connections with dorsolateral prefrontal cortex. Together these results highlight the utility of ERP in understanding the cortical dynamics of decision-making, providing a fuller picture of how neural signals of subjective value emerge in the time leading up to choice.
John Rothrock, MD
Renown Institute Neurosciences
Understanding Migraine: Genetics, Epigenetics and Receptor Sensitivity
November 5, 2013, 2:30 pm, Center for Molecular Medicine, Room 111
Despite its high prevalence, migraine remains poorly understood by the lay public and health care providers (HCPs) alike. Many migraine patients who seek medical attention are disappointed by the experience, and many HCPs feel at a loss when confronted by treatment-refractory patients. That migraine can be difficult to treat is hardly surprising. This common, easily recognized and clinically stereotyped disorder is polygenetic in origin, and the familiar symptoms of migraine consequently may be generated by a variety of biologic pathways. To complicate matters further, the clinical expression of migraine's genetic predisposition may be influenced by a number of factors, epigenetic and otherwise. Finally, migraine is comorbid with conditions and diseases that may complicate management of the headache disorder; these comorbidities include depression, bipolar disorder, anxiety disorders, sleep disorders and epilepsy. Despite this, a better understanding of migraine's biogenesis has led to the development of new therapies relatively specific to the disorder and unprecedented in their efficacy.
Theodore Huppert, PhD
University of Pittsburgh
Introduction to Function Near-Infrared Spectroscopy (fNIRS)
2:30 pm, Tues. December 10th - Ansari 107
In this talk, Dr. Huppert will present the background theory behind fNIRS brain imaging. He will also introduce the basic concepts of data collection, analysis and interpretation of fNIRS.
Illuminating the Mind: Applications and Challenges for fNIRS
2:30 pm, Wed. December 11th - Ansari 107
Functional near-infrared spectroscopy (fNIRS) is a non-invasive brain imaging technique that uses light to record changes in cerebral blood flow. This technology has several unique advantages including low cost, portability, and versatility which have opened several new areas of brain imaging research. In this talk, Dr. Huppert will present an overview of some of these novel applications for fNIRS technology that are being conducted at the University of Pittsburgh, including brain imaging of balance and mobility disorders, child and infant psychology, and multimodal neuroimaging. He will also discuss some of the unique challenges of using fNIRS in "real-world" brain imaging experiments.