My laboratory is interested in the pathogenesis of virus diseases. In the overall area of virus pathogenesis we are interested in the regulation of human cytomegalovirus latency and the pathogenesis of New World Hantaviruses. Cytomegalovirus is a member of the herpes group of viruses. It infects a high percentage of the human population but is most common present as a latent virus infection. My laboratory is interested in the mechanism by which the virus maintains its latent infection and how its activation is regulated.
The second area of interest is the pathogenesis of RNA viruses which are present as epizootic diseases diseases. As a model we are investigating the pathogenesis of New World Hantaviruses. There are several approaches we use to understand the pathogenesis of these viruses in their natural rodent hosts. We are studying natural infections by hantaviruses using catch and release studies to investigate natural hantavirus infections. We are also comparing factors associated with virus disease such as the ability of the virus to induce specific inflammatory cytokines that contribute to viral pathogenesis.
Our laboratory uses a variety of approaches to study virus pathogenesis including the following: 1) nucleic acid sequencing; 2)RNAse protection assays and real time PCR to quantitate virus nucleic acids; 3) In situ hybridization to identify latenly infected cells; 4) expression of virus proteins in herpes virus vectors and other routine molecular biology methods applied to virus diseases.
We would like to acknowledge Turner Biosystems for the grant of a TD 20/20 luminometer. For more information check their Luminometer Grants Website at this link: