The excitatory glutamate receptors and the inhibitory GABA-A receptors are ligand-gated ion channels that play essential roles in the central nervous system. My research team is interested in understanding the cellular and molecular mechanisms underlying the modulations of glutamate and GABA-A receptors by intracellular signals such as kinases and phosphatases. We aim at determining: 1) how these mechanisms mediate the regulation of synaptic plasticity under physiological conditions; 2) why dysfunctional regulations of these receptors contribute to neuronal death and/or neurodegeneration in pathological conditions, and thus providing molecular basis for the development of neuroprotective and neuroregenerative strategies for the treatment of patients suffering from stroke, traumatic brain injury and neurodegenerative diseases. To realize these goals, we have been employing multiple approaches (i.e. electrophysiology, molecular biology and protein biochemistry) and various preparations (i.e. cell lines, primary neuronal cultures, brain slice and in vivo brain tissues) to test our hypotheses in experimental conditions.