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Marie-Louise Ricketts, Ph.D.
Assistant Professor

Marie-Louise Ricketts

Contact Information

Degrees

  • Ph.D., Medicine, University of Birmingham, England, UK, 1998
  • B.S. (Honors), Biomedical Technology, Sheffield Hallam University, UK, 1991

Biography

  • Post-doctoral Fellow, Universite Laval, Quebec City, Canada.
  • Post-doctoral Fellow, Baylor College of Medicine, Houston, TX.
  • Assistant Research Scientist, University of Florida, Gainesville, FL.

Research Interests

Dr Ricketts’s research program is in the areas of molecular nutrition and endocrinology. Her work mainly focuses on understanding the molecular mechanisms underlying the metabolic effects of bioactive dietary constituents/natural products, with an emphasis on the role played by nuclear hormone receptors (NHRs). NHRs are ligand-inducible transcription factors that regulate gene expression by interacting with specific DNA sequences upstream of their target genes, and they are involved in key biological processes including development, reproduction, metabolism, cell growth, differentiation and immunity. Dr Ricketts has extensive experience in elucidating molecular mechanisms of action of bioactive dietary components, e.g. cafestol which acts as an agonist ligand for the farnesoid x receptor and pregnane x receptor to increase serum cholesterol levels. Dr Ricketts has also undertaken research studies regarding nuclear hormone receptor-mediated actions of soy isoflavones. Currently her work focusses on elucidating the molecular mechanisms of action of a grape seed procyanidin extract (GSPE) in order to understand how it regulates triglyceride (TG) homeostasis.

Selected Publications

  • Gianella Caiozzi, Brian S. Wong and M.L.Ricketts* (2012) Dietary modification of metabolic pathways via nuclear hormone receptors
    Cell Biochemistry and Function. 30(7):531-51. *corresponding author
  • Y. Li, Ross-Viola J.S., N.F.Shay, D.D.Moore, and M.L.Ricketts*(2009) Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. J Nutr. 2009 May;139(5):898-904. Epub 2009 Mar 18. *Corresponding author
  • J.M.Del Bas*, M.L.Ricketts*, M.Vaqué, E.Sala, H.Quesada, A.Ardevol, A.M.J.Salvadó, M.Blay, L.Arola, D.D.Moore, G. Pujadas, J. Fernandez-Larrea, C.Bladé (2009) Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner. Molecular Nutrition and Food Research 2009 53(7):805-14 *Equal contribution.
  • J.M.Del Bas, M.L.Ricketts, I.Baiges, H.Quesada, A.Ardevol, M.J.Salvadó, G.Pujadas, M.Blay, L.Arola, C.Bladé, D.D.Moore, J. Fernandez-Larrea (2008) Dietary procyanidins lower triglyceride levels signalling through the nuclear receptor Small heterodimer partner.
    Molecular Nutrition and Food Research. 2008 52(10):1172-81. Epub ahead of print Aug 20 2008
  • M.L.Ricketts* (2007) Does Coffee raise cholesterol..? Invited Editorial Future Lipidology 2(4); 373-377 * Corresponding author
  • M.L.Ricketts*, M.V.Boekschoten, A.J.Kreeft, G.J.Hooiveld, C.J.Moen, M.Muller, R.R.Frants, S.Kasanmoentalib, S.M.Post, H.M.Princen, J.G.Porter, M.B.Katan, M.H.Hofker & D.D.Moore (2007) The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane x receptors. *Corresponding author. Molecular Endocrinology. 21 (7): 1603-1616 (Epub: April 24th 2007)
    Manuscript was featured on the cover of the July 2007 issue
  • F.Durocher, R.Sanchez, M.L.Ricketts, Y.Labrie, V.Laudet, J.Simard (2005)
    Characterization of the guinea pig 3beta-hydroxysteroid dehydrogenase/delta5-delta4-isomerase expressed in the adrenal gland and gonads. Journal of Steroid Biochemistry & Molecular Biology 97(3):289-298 (Epub: Sept 6th 2005)
  • M.L.Ricketts, D.D.Moore, W.J.Banz, O. Mezei, N.F.Shay (2005). Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous receptors. Journal of Nutritional Biochemistry 16(6):321-330
  •  J. Simard, M.L.Ricketts, S.Gingras, P.Soucy, F.A.Feltus, M.H.Melner (2005)
    Molecular Biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4-isomerase gene family. Endocrine Reviews 26(4):525-582. (Epub: Jan 4th 2005).
  • J.Simard, M.L.Ricketts, A.M.Moisan, V. Tardy, M.Peter, Y. Morel (2000) A new insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency. Proceedings from the IXth Adrenal Cortex Conference, Toronto, 18-19th June, 2000. Endocrine Research 26 (4): 761-770.
  • A.K.Agarwal, G.Giacchetti, G.Lavery, H.Nikkila, M.Palermo, M.Ricketts, C.McTernan, G.Bianchi, P.Manunta, P.Strazzulo, F.Mantero, P.C.White, P.M.Stewart. (2000) CA-repeat polymorphism in Intron 1 of HSD11B2: Effects on gene expression and salt sensitivity. Hypertension 36:187-194.
  • A.M.Moisan*, M.L.Ricketts*, V.Tardy, M.Derochers, F.Mébarki et al. (1999) New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: Identification of eight mutations in the HSD3B2 gene in eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes. Journal of Clinical Endocrinology & Metabolism 84: 4410-4425 *Equal first author
  • M.L.Ricketts and P.M.Stewart (1999)
    Regulation of type 2 11-hydroxysteroid dehydrogenase by diuretics and modulators of the renin-angiotensin-aldosterone axis. Clinical Science 96:669-675
  • M.L. Ricketts, J.M. Verhaeg, I.J.Bujalska, A.J. Howie, W.E.Rainey, P.M. Stewart (1998)
    Immunohistochemical localization of type 1 11-hydroxysteroid dehydrogenase in human tissues. Journal of Clinical Endocrinology and Metabolism 83:1325-1335
  • M.L.Ricketts, K.J.Shoesmith, M. Hewison, A. Strain, M.C. Eggo, P.M. Stewart (1998)
    Regulation of 11beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes. Journal of Endocrinology 156:159-168
  • M.Shimojo, M.L.Ricketts, M.D.Petrelli, P.Moradi, G.D.Johnson, A.R.Bradwell, M.Hewison, A.J.Howie and P.M.Stewart (1997)
    Immunodetection of 11beta-hydroxysteroid dehydrogenase type 2 in human mineralocorticoid target tissues: evidence for nuclear localization.
    Endocrinology 138:1305-1311.
  • J.Condon, M.L.Ricketts, C.B.Whorwood, P.M.Stewart (1997) Ontogeny and sexual dimorphic expression of mouse type 2 11beta-hydroxysteroid dehydrogenase Molecular and Cellular Endocrinology 127:121-128
  • M.M.Pasquarette, P.M.Stewart, M.L.Ricketts, K.Imaishi, J.I.Mason (1996) Regulation of 11beta-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells Journal of Molecular Endocrinology 16:269-275
  • C.B.Whorwood, J.I.Mason, M.L.Ricketts, A.J.Howie, P.M.Stewart (1995) Detection of human 11beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts. Molecular and Cellular Endocrinology 110:R7-R12
  • C.B.Whorwood, M.L.Ricketts, P.M.Stewart (1994) Epithelial localization of type 2 11beta-hydroxysteroid dehydrogenase in rat and human colon. Endocrinology 135:2533-2541
  • C.B.Whorwood, M.L.Ricketts, P.M.Stewart (1994) Regulation of Sodium-Potassium Adenosine Triphosphate subunit gene expression by corticosteroids and 11beta-hydroxysteroid dehydrogenase activity. Endocrinology 135:901-910

Courses Taught

  • NUTR 452R Advanced Nutrition 4 credits (Spring semester only)
  • NUTR 485 Nutrition Research and Contemporary Issues 3 credits (Fall only)

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University of Nevada, Reno

University of Nevada, Reno
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Reno,  NV  89557-

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