Jeff Angermann, Ph.D.
- Ph.D., Agricultural and Environmental Chemistry, University of California, Davis, 2003
- B.S., Environmental Toxicology, University of California, Davis, 1992
- Postdoctoral researcher, UNR Department of Pharmacology, 2004-2007
Our group studies the toxicological effects of acute and chronic arsenic exposure at multiple levels of organization, with a primary focus on cardiovascular and metabolic perturbations. We are conducting a ongoing study in rural Bangladesh, where endemic arsenic exposure via tube well water consumption is consistently high. Our initial research trip (December 2013 - January 2014) focused on identification of susceptible populations in the Shariatpur district of Southern central Bangladesh, involving collection of tube well water, biological samples, assessment of clinical signs of arsenicosis, and administration of health effects surveys. Future visits will expand the study, with refined clinical assessments and survey subclinical cardiovascular and metabolic biomarkers of arsenic exposure.
In addition to translational investigations, we are engaged in several projects that elucidate molecular and biochemical mechanisms by which acute and subchronic arsenic exposure affects vascular smooth muscle (VSM) and vascular endothelial (VE) cell function. Current experiments focus on arsenic-induced cell cycle perturbations in VSM and VE model cell lines, induction of reactive oxygen species in VSMCs and VECs, investigation of arsenic-induced dedifferentiation of VSMCs, and assessment of changes in substrate utilization/energy metabolism following acute arsenic exposure in VECs and VSMCs.
- Angermann, J.E., Forrest AS, Greenwood IA, Leblanc N. Activation of Ca2+-activated Cl- channels by store-operated Ca2+ entry in arterial smooth muscle cells does not require reverse-mode Na+/Ca2+ exchange. 2012. Canadian Journal of Physiology and Pharmacology 90(7):903-21
- Forrest A.S., Angermann J.E., Raghunathan R., Lachendro C., Greenwood I.A., Leblanc N. 2010. Intricate interaction between store-operated calcium entry and calcium-activated chloride channels in pulmonary artery smooth muscle cells. Advances in Experimental Medicine and Biology 661:31-55
- Goyal, R., Angermann, J.E., Ostrovskaya, O., Buchholz, J.N., Smith, G.D., and S.M. Wilson. 2009. Enhanced capacitative calcium entry and sarcoplasmic reticulum calcium storage capacity with advanced age in murine mesenteric arterial smooth muscle cells. Experimental Gerontology 44(3): 201-207
- Saleh, S., Angermann, J.E., Leblanc, N. and I. Greenwood. 2007. Stimulation of Ca2+-gated Cl- currents by the calcium-dependent K+ channel modulators NS1619 and isopimaric acid. Journal of Pharmacology and Experimental Therapeutics 321(3): 1075-84
- Angermann, J.E., Sangunietti, A., Leblanc, N. and I.A. Greenwood. 2006. Investigation of the biophysical effect of dephosphorylation on vascular calcium-dependent chloride channels. Journal of General Physiology 128(1): 73-87
- Normand Leblanc, Jonathan Ledoux, Sohag Saleh, Amy Sanguinetti, Jeff Angermann, Kate O'Driscoll, Fiona Britton, Brian A. Perrino, Iain A. Greenwood. 2005. Regulation of Calcium-Activated Chloride Channels in Smooth Muscle Cells - A Complex Picture Is Emerging. Canadian Journal of Physiology and Pharmacology 83(7): 541
- Ohyama, K.I., Angermann, J.E., Dunlap, D.Y. and F. Matsumura. 2004. Distribution of Polychlorinated Biphenyls and Chlorinated Pesticide Residues in Trout in the Sierra Nevada. Journal of Environmental Quality 33(5):1752-64
- Angermann, J.E., Matsumura, F. and G.M. Fellers. 2002. Polychlorinated Biphenyls and Toxaphene in Pacific Treefrogs (Hyla regilla) from the California Sierra Nevada. Environmental Toxicology and Chemistry 21(10): 2209-2215.