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Jim Kenyon, Ph.D.
Professor

Jim Kenyon

Contact Information

Research Interests

Liquid Junction Potential - There are people out there doing electrophysiological experiments who do not understand junction potentials. I know because I get their papers to review. This following link will take you to the famous "Primer on Junction Potentials" that explains how to handle this phenomenon. The link will also enable you to down load a spreadsheet to calculate junction potentials. Click Here For Primer On Junction Potentials. Download a spreadsheet to calculate liquid junction potentials click here.

Single Channel Gating - The opening and closing of single channels is fascinating and also gives me the opportunity to collaborate with my good friend Dr. Bob Bauer. The link here will take you to a summary of our most recent results. Click Here For Single Channel Gating Page.

Diffusion of Ca2+ in the presence of a mobile buffer - The figure shows the profile of free Ca2+ around a Ca2+ channel in the presence of either 1 mM BAPTA or 1 mM EGTA. To download a copy of the Excel spreadsheet that did the calculation and pdf files of pertinent papers by Drs. Neher and Stern click here.

We have recently published a description of an Excel Spreadsheet that calculates the diffusion of Ca2+ in a spherical cell. That paper also examines the measurement of global Ca2+. Although this is commonly taken to be a trivial measurement it is not. The program, a manual, and a copy of the paper can be obtained here.

Intracellular Calcium in Sensory Neurons - Recent work in the laboratory has investigated the mechanisms that control intracellular calcium in primary afferent neurons. Publications are listed below. The link here will take you to a brief summary of recent results. Click Here For the Spatial Relationships Between Ca channels and Ca-activated channels.

The Hodgkin-Huxley Equations - In honor of the 50th anniversary of the publication of the equations that have provided support for me and my family these many years, I am posting a tutorial of how to solve the equations. The link here will let you download my primer on the equations and two spreadsheets that use the equations to calculate currents and a squid action potential. Click here For the Hodgkin-Huxley Page.

The major research effort in the laboratory concerns the regulation of intracellular calcium in developing neurons and the function of potassium channels in smooth muscle. We use patch-clamp techniques to record membrane currents from cultured sensory neurons, fluorescence measurements of intracellular calcium, and molecular techniques to characterize potassium channels and their regulation by protein kinases and phosphatases.

The major research effort in the laboratory concerns the regulation of intracellular calcium in developing neurons and the function of potassium channels in smooth muscle. We use patch-clamp techniques to record membrane currents from cultured sensory neurons, fluorescence measurements of intracellular calcium, and molecular techniques to characterize potassium channels and their regulation by protein kinases and phosphatases.

The figure shows membrane currents recorded using the whole cell patch-clamp technique from two chick dorsal root ganglion neurons during depolarizations of 10, 50, and 170 ms duration (two chick dorsal root ganglion neurons during depolarizations of 10, 50, and 170 ms duration (top traces). The depolarizations activate N-type calcium currents. Calcium influx raises intracellular calcium and thereby activates calcium-activated chloride currents that are outward during the depolarization and inward following repolarization. At the higher temperature, the amplitude and rate of deactivation of the currents is increased. For more, see papers by Kenyon and Goff and by Ward and Kenyon listed below.

Publications

PubMed

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