Scholar: Megan Tillman
Major: Biochemistry, Molecular Biology, and Neuroscience
Faculty Mentors: Dr. Ronald Pardini
Research Topic: Effect of Eicosapentaenoic Acid on A549 cells
Abstract: Cancer is the second leading cause of death in the United States. Researchers have found that docosahexaenoic acid and eicosapentaenoic acid can inhibit the progression of tumors in various organs especially the breast and prostate. In this study, we particularly focus on eicosapentaenoic acid's effect on A549 cells, which is an aggressive lung cancer cell line and compare its effect to the effect of docosahexaenoic acid and lineolic acid-a main component of the western diet. We have found cell proliferation decreases when treated with eicosapentaenoic acid and docosahexaenoic acid. Lineolic acid also decreases cell proliferation but not as much as eicosapentaenoic acid and docosahexaenoic acid. It was also found that the IC50 of eicosapentaenoic too is 100uM. This makes it possible for us to analyze the total oxidative stress, lipid peroxide level of the cells at this concentration, and concentrations around 100uM of eicosapentaenoic acid. After that, it will be possible to measure the eicosanoid levels in response to eicosapentaenoic acid since it has been reported that eicosapentaenoic acid has a higher level of eicosanoid levels than docosahexaenoic acid.
New Scholar: 2011
Graduating With Baccalaureate Degree: 2012