Brian A. Perrino
Department: Physiology & Cell Biology
Academic Unit: School of Medicine
Title: Associate Professor
Professional degrees (Degree, year, Institution): PhD, 1989, Boston University
Mail Stop: 352
Physiology, Cell Biology
We are investigating the molecular changes to Ca2+-dependent intracellular signaling occurring within gut smooth muscle cells as a consequence of inflammation or diabetes. This approach may lead to improvements in therapies aimed at relieving symptoms and restoring normal gut motility. Regulation of intracellular Ca2+ signaling by sarcoplasmic reticulum Ca2+ cycling plays a key role in GI smooth muscle contractility. In cardiac and vascular smooth muscles, many of the signaling pathways involved in the induction of pathological remodeling are linked to SR Ca2+ cycling. Similarly, emerging evidence implicates dysregulation of intracellular Ca2+ cycling in gut motility disorders. These recent findings are providing important clues to the biochemical and molecular basis for the functional changes in gut smooth muscles that give rise to digestive tract dysmotility.
Current Graduate Students
Sadeea Qureshi: MD/PhD Candidate
Bhupal Phetwal: PhD Candidate
of murine gastric antrum smooth muscle STOC activity and excitability by
Kim M, Hennig GW, Park K, Han IS, Smith TK, Koh SD, Perrino BA.
J Physiol. 2008 Oct 15;586(Pt 20):4977-91. Epub 2008 Aug 28.
PMID: 18755751 [PubMed - indexed for MEDLINE]
of SRF/CArG-dependent gene transcription during chronic partial obstruction
of murine small intestine.
Chen J, Chen H, Sanders KM, Perrino BA.
Neurogastroenterol Motil. 2008 Jul;20(7):829-42.
PMID: 18557893 [PubMed - indexed for MEDLINE]
Phospholamban knockout increases CaM kinase II activity and intracellular Ca2+ wave activity and alters contractile responses of murine gastric antrum.
Kim M, Hennig GW, Smith TK, Perrino BA.
Am J Physiol Cell Physiol. 2008 Feb;294(2):C432-41. Epub 2007 Nov 28.
PMID: 18045856 [PubMed - indexed for MEDLINE]
translocation of calcineurin Abeta but not calcineurin Aalpha by platelet-derived
growth factor in rat aortic smooth muscle.
Jabr RI, Wilson AJ, Riddervold MH, Jenkins AH, Perrino BA, Clapp LH.
Am J Physiol Cell Physiol. 2007 Jun;292(6):C2213-25. Epub 2007 Feb 15.
PMID: 17303652 [PubMed - indexed for MEDLINE]
kinase II activation and phospholamban phosphorylation by SNP in murine
gastric antrum smooth muscles.
Kim M, Perrino BA.
Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1045-54. Epub 2006 Dec 21.
PMID: 17185633 [PubMed - indexed for MEDLINE]
Faculty by research area
- Mastick, C
- Mastick C.
- Mastick G.
- Van der Linden
- von Bartheld
- von Bartheld