Thomas W. Bell
Academic Unit: Science
Professional degrees: B.S. California Institute of Technology, Ph.D. University College, London
Mail Stop: 216
Phone: 775-784 1842
Fax: 775-784 6804
Our major research area is medicinal chemistry and we are especially interested in designing and discovering novel antiviral drugs. For example, we have synthesized a series of new drugs called CADA compounds, which inhibit entry of the HIV virus into host cells. This is accomplished by down-modulating CD4, the cell-surface receptor required for binding of the virus. CADA compounds do this by inhibiting post-translational translocation of nascent CD4 across the ER membrane. Current work is aimed at determining the exact molecular mechanism by which CADA compounds perform this unique task.
Current Graduate Students:
Jenabian MA, Saïdi H, Charpentier C, Bouhlal H, Schols D, Balzarini J, Bell TW, Vanham G, Bélec L. Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization. AIDS Res Ther. 2010 Jun 14;7:16-23.
Vermeire K, Van Laethem K, Janssens W, Bell TW, Schols D. Human immunodeficiency virus type 1 escape from cyclotriazadisulfonamide-induced CD4-targeted entry inhibition is associated with increased neutralizing antibody susceptibility. J Virol. 2009 Sep;83(18):9577-83.
Vermeire K, Brouwers J, Van Herrewege Y, Le Grand R, Vanham G, Augustijns P, Bell TW, Schols D. CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor. Curr HIV Res. 2008 May;6(3):246-56.
Vermeire K, Lisco A, Grivel JC, Scarbrough E, Dey K, Duffy N, Margolis L, Bell TW, Schols D. Design and cellular kinetics of dansyl-labeled CADA derivatives with anti-HIV and CD4 receptor down-modulating activity.
Biochem Pharmacol. 2007 Aug 15;74(4):566-78.
Bell TW, Anugu S, Bailey P, Catalano VJ, Dey K, Drew MG, Duffy NH, Jin Q, Samala MF, Sodoma A, Welch WH, Schols D, Vermeire K. Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogs. J Med Chem. 2006 Feb 23;49(4):1291-312.
Faculty by research area
- Mastick, C
- Mastick C.
- Mastick G.
- Van der Linden
- von Bartheld
- von Bartheld