David P. AuCoin

Department: Microbiology and Immunology
Academic Unit: Medicine
Title: Research Assistant Professor
Professional degrees:
B.S.  University of Massachusetts at Amherst
M.S.  Univeristy of Nevada, Reno
 Ph.D. University of Nevada, Reno           

Contact Information

Mail Stop: 320
Phone: 775-784 4128
Fax: 775-327-2332
e-mail: daucoin@medicine.nevada.edu

 

Research Interests

Our research utilizes proteomic techniques to identify bacterial antigens that are secreted during infection.  Currently, we are studying Burkholderia pseudomallei, Francisella tularensis, and Bacillus anthracis.  The overall goal is to produce monoclonal antibodies that are specific to secreted antigens for the production of antigen-capture immunoassays for rapid diagnosis of infections.   Bacterial antigens that are secreted in vivo can also be targeted during infection with monoclonal antibodies.  Our lab is involved in producing IgG subclass switch variants and mouse/human chimeric mAbs in order to passively treat bacterial infections.

Current Graduate Students:

Mark Hubbard
Farida Dwi Handayani

Other lab members

Reva Crump (Research Assistant IV)

Selected Publications

AuCoin DP, Sutherland MD, Percival AL, Lyons CR, Lovchik JA, Kozel TR. Rapid detection of the poly-gamma-d-glutamic acid capsular antigen of Bacillus anthracis by latex agglutination. Diagn Microbiol Infect Dis. 2009 Apr 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/19345041?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Kozel TR, Thorkildson P, Brandt S, Welch WH, Lovchik JA, AuCoin DP, Vilai J, Lyons CR. Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule. Infect Immun. 2007 Jan;75(1):152-63. Epub 2006 Oct 23
http://www.ncbi.nlm.nih.gov/pubmed/17060470?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

AuCoin DP, Smith GB, Meiering CD, Mocarski ES. Betaherpesvirus-conserved cytomegalovirus tegument protein ppUL32 (pp150) controls cytoplasmic events during virion maturation. J Virol. 2006 Aug;80(16):8199-210.
http://www.ncbi.nlm.nih.gov/pubmed/16873276?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

AuCoin DP, Colletti KS, Cei SA, Papousková I, Tarrant M, Pari GS. Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP).
Virology. 2004 Jan 20;318(2):542-55.
http://www.ncbi.nlm.nih.gov/pubmed/14972523?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

AuCoin DP, Colletti KS, Xu Y, Cei SA, Pari GS.  Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains two functional lytic origins of DNA replication. J Virol. 2002 Aug;76(15):7890-6.