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Substance-using Women and Drug-exposed Infants: 
Module Two - Other Drugs
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Signs and Symptoms of Drug Withdrawal

cyan_bul.gif (1138 bytes) BARBITURATE ABSTINENCE SYNDROME
The barbiturate abstinence syndrome begins 6 to 24 hours after the last dose, and symptoms are generally more severe with the short-acting barbiturates. Signs and symptoms of barbiturate abstinence include:
• Tremulousness 
• Diaphoresis
• Anxiety
• Postural hypotension
• Insomnia
• Grand mal convulsions
(between days 3 and 7)
• Agitation
• Anorexia
• Delirium
• Nausea and vomiting
• Tendon hyperreflexia
Note: If untreated, withdrawal symptoms can progress to hyperpyrexia, electrolyte abnormalities, cardiovascular collapse, and death.

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Page last updated May 05, 2001