Substance-using Women and Drug-exposed Infants


Module Two: Other Drugs

Signs and Symptoms of Drug Withdrawal

Alcohol
Early symptoms of alcohol withdrawal generally appear 6 to 48 hours after drinking has stopped but can occur up to 10 days after the last drink. Withdrawal symptoms may include:
• Restlessness
• Tachycardia
• Irritability
• Hypertension
• Anorexia
• Insomnia
• Nausea
• Nightmares
• Vomiting
• Impaired concentration
• Sweating
• Impaired memory
• Tremors
• Elevated vital signs
More severe symptoms of alcohol withdrawal may include
• Increased tremulousness
• Increased agitation
• Increased sweating
• Delirium (with confusion, disorientation,
   impaired memory and judgment)
• Hallucinations (auditory, visual, or tactile)
• Delusions (usually paranoid)
• Grand mal seizures
Note: Withdrawal symptoms do not necessarily progress from mild to severe. In some individuals, a grand mal seizure may be the first sign of withdrawal. Seizures usually occur 12 to 24 hours after cessation or reduction of drinking. One-third of all patients who have seizures develop delirium tremens.
Opioids
Mild withdrawal signs and symptoms include:
• Generalized anxiety
• Opioid craving
• Restlessness
• Slight aching of muscles, joints, and bones
• Lower back pain
Mild to moderate withdrawal signs and symptoms include:
• Tension
• Yen sleep (mild insomnia)
• Mydriasis (pupils dilated)
• Lethargy
• Diaphoresis (usually perspiration)
Moderate withdrawal signs and symptoms include:
• Chills alternating with flushing and
   diaphoresis (sweating)
• Rhinorrhea (runny nose)
• Moderate aching of muscles,
   joints and bones
• Lower back pain
• Anorexia
• Nausea and/or stomach cramps
• Yawning
• Lacrimation (tearing)
• Goose flesh (earlier if client is in
   a cold, drafty room)
• Elevated pulse and blood pressure
Moderate to severe withdrawal signs and symptoms include:
• Tachycardia
(pulse over 100 BPM)
• Increased respiratory rate and depth
• Diarrhea
• Vomiting
• Tremors
Severe withdrawal signs and symptoms include:
• Doubling over with stomach cramps
• Kicking movements 
• Elevated temperature
(usually low grade, less than 100 degrees F)
Note: Withdrawal signs and symptoms differ in their order of appearance from one individual to another. Some individuals may not exhibit certain withdrawal signs and symptoms. Signs may also include uterine irritability, increased fetal activity, or rarely, hypotension.
Barbiturate Abstinence Syndrome
The barbiturate abstinence syndrome begins 6 to 24 hours after the last dose, and symptoms are generally more severe with the short-acting barbiturates. Signs and symptoms of barbiturate abstinence include:
• Tremulousness 
• Diaphoresis
• Anxiety
• Postural hypotension
• Insomnia
• Grand mal convulsions
(between days 3 and 7)
• Agitation
• Anorexia
• Delirium
• Nausea and vomiting
• Tendon hyperreflexia
Note: If untreated, withdrawal symptoms can progress to hyperpyrexia, electrolyte abnormalities, cardiovascular collapse, and death.
Cocaine
Withdrawal from cocaine dependence is characterized by depression, anxiety, and lethargy, which begin to resolve after approximately 1 week. Less common are signs of a paranoid psychosis during withdrawal from chronic use of high doses of cocaine. In cocaine withdrawal, medication is rarely needed for the serious sequelae that are associated with alcohol, barbiturate, and opioid withdrawal.