Stephen St. Jeor, Ph.D.
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Research Interests:
My laboratory is interested in the pathogenesis of virus diseases. In the overall area of virus pathogenesis we are interested in the regulation of human cytomegalovirus latency and the pathogenesis of New World Hantaviruses. Cytomegalovirus is a member of the herpes group of viruses. It infects a high percentage of the human population but is most common present as a latent virus infection. My laboratory is interested in the mechanism by which the virus maintains its latent infection and how its activation is regulated.
The second area of interest is the pathogenesis of RNA viruses which are present as epizootic diseases diseases. As a model we are investigating the pathogenesis of New World Hantaviruses. There are several approaches we use to understand the pathogenesis of these viruses in their natural rodent hosts. We are studying natural infections by hantaviruses using catch and release studies to investigate natural hantavirus infections. We are also comparing factors associated with virus disease such as the ability of the virus to induce specific inflammatory cytokines that contribute to viral pathogenesis.
Selected Publications:
Rizvanov, Albert A., A. van Geelen, S. Morzunov, E. Otteson, C. Bohlman, G. Pari, and S. St. Jeor, 2003. Generation of a recombinant cytomegalovirus for expression of a hantavirus glycoprotein. J. Virol., Nov, v 77, no. 22.
Aviles, G., J. Meissner, R., Mantovani, and S. St. Jeor. Complete coding sequences of dengue-1 viruses from Paraguay Complete coding sequences of dengue-1 viruses from Paraguay and Argentina. Virus Research, 98, 2003, 75-82.
Pini, N., Levis, S. Calderon, G., Ramirez, J., Bravo, D. Lozano, E. Ripoll, C., St. Jeor, S. Kziazek, T.G. Barquez, R.M., Enria, D. Hantavirus infection in humans and rodents, northwestern Argentina. Emerg. Infect. Dis. 2003, Sep;9(9):1070-6.
Crapnell, K.B., Almeida-Porado, G. Khaiboullina, S., St. Jeor, S.C., Zanjani, E.D. Human haematopoietic stem cells that mediate long-term in vivo engraftment are not susceptible to infection by human cytomegalovirus. Br. J. Haematol. 2004, Mar;124(5):676-84.
Varough Deyde1, Albert Rizvanov, Elmer Otteson, Suzanne Brandt, Mariana Bego, Gregory Pari, Thomas Kozel and Stephen St Jeor Identification of a monoclonal antibody from peromyscus maniculatus (deer mouse) cytomegalovirus (PCMV) which binds to a protein with homology to the human CMV martix protein HCMV, J. Virol. Methods, accepted (2004).
Albert A. Rizvanov*, Svetlana F. Khaiboullina*, and Stephen St. Jeor. Development of reassortant viruses between pathogenic hantavirus strains Albert A. Rizvanov, Svetlana F. Khaiboullina, Albert G.M. van Geelen and Stephen C. St. Jeor. Virology. 2004; 327:225-232.
Khaiboullina, S.F., A. Rizvanov, E. Otteson, D. Miyazato, J. Maciejewski, and S. St. Jeor. 2004. Regulation of cellular gene expression in endothelial cells by sin nombre and prospect hill viruses. Viral Immunology. 17:234-251.
Khaiboullina S.F., JP Maciejewski, K Crapnell, PA. Spallone, AD Stock, GS Pari, ED Zanjani, and S. St. Jeor. 2004. Human Cytomegalovirus Persists in Myeloid Progenitors and is passed to the myeloid progeny in a latent form. Br. J Hemahology. 126:410-417.
Khaiboullina S. F., A A. Rizvanov, M R. Holbrook, and S. St. Jeor. 2004. Yellow fever virus strains Asibi and 17d-204 infect human umbilical cord endothelial cells and induce novel changes in gene expression. Virology. accepted with revisions.
Khaiboullina, S. F., A.A. Rizvanov, V.M. Deyde, and S.C. St .Jeor 2005. Andes virus stimulates interferon-inducible mxa protein expression in endothelial cells. J Med Virol. 75:267-
Levis S, Garcia J, Pini N, Calderon G, Ramirez J, Bravo D, St Jeor S, Ripoll C, Bego M, Lozano E, Barquez R, Ksiazek TG, Enria D. Hantavirus pulmonary syndrome in northwestern Argentina: circulation of Laguna Negra virus associated with Calomys callosus. Am J Trop Med Hyg. 2004
Lahijani, R.S., E.W. Otteson, and S. St. Jeor. 1992. A possible role for nonsense suppression in the synthesis of a human cytomegalovirus 58-kDa virion protein. Virology, 186:309-312.
Maciejewski, J., E. Bruening, E. Mocarski, N. Young, and S.C. St. Jeor. 1992. Infection of hematopoietic progenitor cells by human cytomegalovirus. Blood. 80:170-178.
Maciejewski, J., E. Bruening, R. Donahue, S. Sellers, C. Carter, N. Young, and S. St. Jeor. 1993. Infection of mononucleated phagocytes with human cytomegalovirus. Virology. 195:327-336.
Rowe, Joan E., Stephen C. St. Jeor, Jeffrey Riolo, Elmer W. Otteson, Martha C. Monroe, Thomas G. Ksiazek, Pierre E. Rollin, and Stuart T. Nichol. 1995. Coexistence of several novel hantaviruses in rodents indigenous to North America. Virology. 213:122-130.
Henderson, Winnie W., Martha C. Monroe, Stephen C. St. Jeor, Wesley P. Thayer, Joan E. Rowe, C.J. Peters, and Stuart T. Nichol. 1995. Naturally occurring Sin Nombre virus genetic reassortants. Virology. 214:602-610.
Otteson, Elmer W., Jeffrey Riolo, Joan E. Rowe, Stuart T. Nichol, Thomas G. Ksiazek, Pierre E. Rollin, & Stephen C. St. Jeor. 1996. Occurrence of hantavirus within the rodent population of northeastern California and Nevada. J Trop Med & Hygiene. 54(2):127-133.
Levis, Silvana, Joan E. Rowe, Sergey Morzunov, Delia A. Enria, and Stephen St. Jeor. 1997. New hantaviruses causing HPS in Central Argentina. The Lancet, Apr 5:349(9057):998-9.
Zhuravskaya, T., J.P. Maciejewski, D.M. Netski, F.R. Mackintosh, and S. St. Jeor. 1997. Spread of human cytomegalovirus after infection of human hematopoietic progenitor cells. Model of HCMV latency. Blood. 90:2482-2491.
Levis, Silvana, Sergey P. Morzunov, Joan E. Rowe, Delia Enria, Noemi Pini, Gladys Calderon, Martha Sabattini, and Stephen St. Jeor. 1998. Genetic diversity and epidemiology of hantaviruses in Argentina. J. Inf. Disease. 177:529-38.
Morzunov, Sergey P., Joan E. Rowe, Thomas G. Ksiazek, Clarence J. Peters, Stephen C. St. Jeor, and S. T. Nichol. 1998. Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in N. A. J. Virology. 72:57-64.
Boone, John D., Elmer W. Otteson, Pascal Villard, Kenneth C. McGwire, Joan E. Rowe, and Stephen St. Jeor. 1998. Ecology and demographics on hantavirus infections in rodent populations in the Walker River basin of Nevada and California. Am. J. Trop. Med. Hyg. 59(3):445-451.
Prichard, Mark, N., Sanju Jairath, Mark E.T. Penfold, Stephen St. Jeor, Marlene C. Bohlman, and Gregory S. Pari. 1998. Identification of persistent RNA-DNA hybrid structures within the origin of replication of human cytomegalovirus. In Press. J. Virology.
Netski, Dale, Brandolyn Ross, and Stephen St. Jeor. 1999. Sin Nombre virus pathogenesis in Peromyscus maniculatus. J. Virology. J. 73: 585-591.
Feuer, Ralph, John D. Boone, Dale Netski, Sergey P. Morzunov, and Stephen C. St. Jeor. 1999. Temporal and spatial analysis of Sin Nombre virus quasispecies in naturally Infected rodents. J. Virology. November. Vol II. 73:9544-9554.
Borucki, M.K., J.D. Boone, J.E. Rowe, M.C. Bohlman, E.A. Kuhn, R. DeBaca, and S.C. St. Jeor. 2000. The role of maternal antibody in natural infection of peromyscus maniculatus with sin Nombre Virus. J. Virology. 74:2426-2429.
Boone, John D., Kenneth C. McGwire, Elmer W. Otteson, Pascal Villard, Peter Brussard, and Stephen St. Jeor. 2000. Remote sensing and geographic information system maps as indicators of the spatial pattern on Sin Nombre virus infections in deer mice (Peromyscus maniculatus). Emerging Infectious Disease. 6:248-258.
Lobas, Jeffrey, M.D., Jeffrey J. Smith, M.D., and Mary D. Moore, M.D., Charles Grose, M.D., Joan E. Rowe, B.S., and Stephen C. St. Jeor, Ph.D.. 2000. Genetic analysis of Sin Nombre hantavirus in Iowa. Pediatric Infectious Disease J. 19:355-358.
Garcia, J.B., S.P. Morzunov, S. Levis, J. Rowe, G. Calderon, D. Enria, M. Sabattini, M.J. Buchmeier, M.D. Bowen, and S.C. St. Jeor. 2000. Genetic Diversity of the Junin Virus in Argentina: Geographic and Temporal Patterns. Virology. 272:127-136.