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John L. Sutko, Ph.D
Research Interests: Primary research interests involve the regulation of differentiation and phenotype selection during development of embryonic skeletal muscle and nerve. In particular, the temporal and spatial signals involved in the assembly of intracellular calcium release systems and the subsequent role of calcium release events in regulating further differentiation of these tissues are being investigated. Recent Publications: Ouyang, Y., Martone, M.E., Deerinck, T.J., Airey, J.A., Sutko, J.L., and Ellisman, M.H. (1997). Differential distribution and subcellular localization of ryanodine receptor isoforms in the chicken cerebellum during development. Brain Res. 775, 52-62. Sutko, J.L., Airey, J.A., Welch, W., and Ruest, L. (1997). The pharmacology of ryanodine and related compounds. Pharmacol.Rev. 49, 53-98. Welch, W., Williams, A.J., Tinker, A., Mitchell, K.E., Deslongchamps, P., Lamothe, J., Gerzon, K., Bidasee, K.R., Besch, H.R.J., Airey, J.A., Sutko, J.L., and Ruest, L. (1997). Structural components of ryanodine responsible for modulation of sarcoplasmic reticulum calcium channel function. Biochemistry 36, 2939-2950. Tanna, B., Welch, W., Ruest, L., Sutko, J.L., and Williams, A.J. (1998). Interactions of a reversible ryanoid (21-amino-9alpha-hydroxy- ryanodine) with single sheep cardiac ryanodine receptor channels. J.Gen.Physiol. 112, 55-69.
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