University of nevada, Reno Cell and Molecular Biology

David A. Lightner, Ph.D.

Phone: (775) 784-4980

Fax: (775) 784-6804

E-mail: lightner @scs.unr.edu

Personal Web Page: Click Here

Research Interests:

Current research is directed toward synthesis, stereochemistry and photochemistry, with an emphasis on (i) synthetic analogs of bilirubin, the yellow pigment of jaundice, (ii) organic conformational analysis from circular dichroism and NMR spectroscopy; (iii) photobiology, molecular mechanisms of phototherapy for neonatal jaundice, bilirubin metabolism, pyrrole chemistry and photochemistry, photooxidation and singlet oxygen, (iv) chiral molecular recognition; (v) chiroptical properties and electronic interaction of non-adjacent chromophores, long-range interactions; (vi) exciton interactions in organic and biological systems as detected by circular dichroism; and (vii) stereochemistry of cyclic ketones and the Octant Rule.

Selected Publications

Syntheses and Metabolism of the First Thia-Bilirubin. Tipton, A.K.; Lightner, D.A.; McDonagh, A.F. J. Org. Chem. 2001, 66, 1832-1838.

Aromatic Congeners of Bilirubin. Synthesis, Stereochemistry, Glucuronidation and Hepatic Transport. Brower, J.O.; Lightner, D.A.; McDonagh, A.F. Tetrahedron 2001, 57, 7813-7827.

Biliary Excretion of a Stretched Bilirubin in UGT1A1-Deficient (Gunn) and Mrp2-deficient (TR–) Rats. McDonagh, A.F.; Lightner, D.A.; Nogales, D.F.; Norona, W. FEBS Lett 2001, 506, 211-215.

A Water-Soluble Synthetic Bilirubin with Carboxyl Groups Replaced by Sulfonyl. Boiadjiev, S.E.; Lightner, D.A., Monatsh. Chem., 2001, 10, 1201-1212.

An Enantiomerically Pure Bilirubin. Absolute Configuration of (aR,a¢R)-Dimethyl-mesobilirubin-XIIIa. Boiadjiev, S.E.; Lightner, D.A. Tetrahedron: Asymm. 2001, 12, 2551-2564.

A C–H···O=C Hydrogen Bond? Intramolecular Hydrogen Bonding in a Novel Semirubin. Huggins, M.T.; Lightner, D.A. J. Org. Chem. 2001, 66, 8402-8410.

Structure and Metabolism of Natural and Synthetic Bilirubins. Lightner, D.A., McDonagh, A.F. J. Perinatol., 2001, 21, S13-S16.

Synthesis and Spectroscopic Properties of a New Class of Highly Fluorescent Dipyrrinones. Brower, J.O.; Lightner, D.A. J. Org. Chem., 2002, in press.

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