CA Pritsos
 |
|||||
| Phone: (775) 327-5096 |
| Fax: (775) 784-6449 |
| E-mail: pritsos@unr.edu |
Research Interests:
My laboratory is involved in a number of studies related to the toxicity and risk of disease associated with exposure to secondhand smoke (SHS). SHS represents a mixture of over 4,000 compounds emitted during smoking including a great number of carcinogens, mutagens, and other highly toxic compounds. We are currently funded to investigate the impact of air filtration systems on reducing the biological damage caused by secondhand smoke. Mice exposed to SHS for 8 weeks will be monitored for biological damage including DNA damage and oxidative damage as well as for immunological changes in the lung. We are also interested in the effects genetic polymorphisms of important detoxification enzymes play in the initiation and progression of disease in SHS exposed individuals. My laboratory also conducts studies which look at the mechanism of action of several bioreductive anticancer agents and the biological effects of low dose exposure of non-target species to anticholinesterase agrochemicals.
Selected Publications:
NJ Martin, AC Collier, LD Bowen, KL Pritsos, GG Goodrich, K Arger, GC Cutter and CA Pritsos, Polymorphisms in the NQO1, GSTT and GSTM genes are associated with coronary heart disease and biomarkers of oxidative stress. Mutation Research-Genetic Toxicology and Environmental Mutagenesis, IN PRESS
J.M. Brasel, A.C. Collier and C.A. Pritsos, “Differential toxic effects of Carbofuran and Diazinon on time of flight in pigeon (Columbia livia): Potential for pesticide effects on migration.” Tox. Appl. Pharmacol. 219:241-246 (2007).
A.C. Collier, K.L. Pritsos and C.A. Pritsos, “TCDD enhances the toxicity of Mitomycin C through Aryl-hydrocarbon receptor interaction and enzyme effects under aerobic but not hypoxic conditions.” Life Sci. 78:1499-1507 (2006).
J.M. Brasel, R.C. Cooper and C.A. Pritsos, “Effects of environmentally doses of cyanide on flight times in pigeons, Columbia, livia.” Bull. Environ. Contam. Toxicol. 76:202-209 (2006).
Search For Dr. Pritsos's Publications In PubMed