Mihalis I. Panagiotidis, PhD
 |
|
Research Interests:
1. Involvement of oxidants and antioxidants during the multistage process of carcinogenesis.
2. Oxidative stress and epigenetic regulation of apoptotic gene expression during carcinogenesis.
3. Dietary modulation of gene expression during carcinogenesis with emphasis for therapeutic intervention.
4. Development of molecular biomarkers in assessing carcinogenic exposure, cancer prognosis, diagnosis and chemotherapeutic efficacy.
Selected Publications:
1. Panayiotidis M, Rancourt R, Allen C, Riddle S, Schneider K, Ahmad S, White CW. Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells. Antiox Redox Signal 6(1):129-136, 2004
2. Panayiotidis MI, Stabler SP, Allen RH, Ahmad A, White CW. Increases of S-adenosylmethionine (SAM) and cystathionine in human A549 lung epithelial-like cells exposed to cigarette smoke extract (CSE). Chemico-Biological Interactions 147(1): 87-97, 2004
3. Panayiotidis MI, Stabler SP, Ahmad A, Pappa A, Legros Jr LH, Hernandez D, Schneider K, Allen RH, Vasiliou V, McCord JM, Kotb M, White CW. Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosyl methionine turnover in lung epithelial cells exposed to hyperoxia. Free Rad Biol Med 40(2): 348-358, 2006
4. Panayiotidis MI, Rancourt RC, Pappa A, White CW. Effect of cell cycle growth arrest on global DNA methylation status in human lung epithelial-like (A549) cells. In Vivo 20: 861-866, 2006
5. Pappa A, Franco R, Schoneveld O, Galanis A, Sandaltzopoulos R and Panayiotidis MI. Sulfur-containing compounds in protecting against oxidant-mediated lung diseases. Current Medicinal Chemistry 14: 2590-2596, 2007
6. Franco R, Schoneveld O, Pappa A and Panayiotidis MI. ? central role of glutathione in the pathophysiology of human diseases. Archives of Physiology and Biochemistry (in press)
7. Franco R, Panayiotidis MI, Cidlowski JA. Glutathione Depletion is Necessary for Apoptosis in Lymphoid Cells Independent of Reactive Oxygen Species Formation. Journal of Biological Chemistry (in press)
Assistant Professor
Environmental & Occupational Health
School of Public Health / MS-274
University of Nevada at Reno
Reno, NV 89557