Research Interests:

RESEARCH INTERESTS:

Human papillomaviruses (HPV) have been implicated in the etiology of benign and malignant lesions of the urogenital tract and upper respiratory system and have been reported in normal and neoplastic colon tissues. We have been investigating cytokine and cell surface molecule production by HPV infected/transfected cells and their relationship to the immyne response to HPV infections.

Enteropathogenic, enterotoxin-producing E. coli 0157:H7 have been widely studied as the cause of outbreaks of food borne disease. However, worldwide, several additional strains of E. coli have been implicated in outbreaks of food borne disease. We are currently investigating the epidemiology and prevalence of non-0157:H7 enterotoxin-producing E. coli in beef cattle raised under rangeland conditions typical of the west ans southwest U.S.

Beef cattle raised under range conditions of the western United States are exposed to a tick-vectored abortagenic disease called Epizootic Bovine Abortion (EBA). W, in collaboration with colleagues from the University of California at Davis, are investigating the geographic distribution of the tick vector, as well as the epidemiology, molecular biology and immunogenic properties of the disease agent. Several vaccine formulations to prevent EBA have been produced and tested.

Recent Publications:

Mohammadpour, H., M.R. Hall, R.S. Pardini, L. Pardini, S.F. Khaiboullina, P. Manalo, and D.B. McGregor. 2000. Tumor development and cytokine production by human colon tissues and carcinoma cell lines. Int. J. Surg. Inv. 2:65-72.

Thran, B.H., H.S. Hussein, S.F. Khaiboullina and M.R. Hall. 2001. Occurence of verotoxin-producing Escherichia coli in dairy heifers grazing an irrigated pasture. Toxicology 159:159-169.

Stott J.L., M.T. Blanchard, M. Anderson, J. Maas, R.L. Walker, P.C. Kennedy, B.B. Norman, R.H. BonDurant, M.N. Oliver, S.F. Khaiboullina, D. Hanks and M.R. Hall. 2002. Experimental transmission of epizootic bovine abortion (foothill abortion) and preliminary classification of the etiologic agent. Vet. Micro 88:161-173.

Hall, M.R., Hanks, D., W.G. Kvasnicka, A. Bosomworth, H. Smith, M. Blanchard, J. Stott and M. Anderson. 2002. Diagnosis of epizootic abortion and identification of the vector in Nevada. J. Vet. Diag. Invest. 14:205-210.

Kato, T., R. Hancock. M. Mohammadpour, B. McGregor, P. Manalo, S. Khaiboullina, M.R. Hall, L. Pardini and R.S. Pardini. 2002. Influence of Omega-3 fatty acids on the growth of human colon carcinoma in nude mice. Cancer Letters 187:169-177.

Thran, B., M.R. Hall, S.F. Khaiboullina and H.S. Hussein. 2003. Non-O157:H7 verotoxin-producing Escherichia coli in healthy beef heifers. J. Exptl. Biol. Med. 228:352-357.

Hussein, H.S., B.H. Thran and M.R. Hall. 2004. Sorbitol-Negative Shiga Toxin-Producing Escherichia coli in Beef Heifers Grazing Rangeland Forages. Prof. Anim. Sci. 20:218-224.