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Research
Interests: The
broad interests of our laboratory are those of receptor-signal
transduction in mammalian systems. We approach our interests with modern
biochemical and molecular methods that include intracellular imaging of
events such as calcium release. One of our principal interests, for
example, is the problem of premature delivery of babies. The signals that
initiate contraction of the uterus at the time of labor are not known. We
have recently described the contractile actions of adenyl purines on the
smooth muscle of guinea pig uterus and find that the receptor that
mediates the contraction of the tissue changes its coupling mechanism
significantly during pregnancy in a fashion consistent with a role for
these compounds in human parturition. The problem of premature delivery is
a devastating human problem that takes its toll both in lives and dollars.
We hope to contribute to an understanding of the onset of labor in order
to help eliminate the problem of premature delivery. Recent
Publications Shuttleworth,
C.W., Weinert, J.S., Sanders, K.M., and Buxton, I.L. (1995). Detection of
nitric oxide release from canine enteric neurons. J.Auton.Nerv.Syst. 56,
61-68. Zhang,
L., Bradley, M.E., and Buxton, I.L. (1995). Inositolpolyphosphate binding
sites and their likely role in calcium regulation in smooth muscle.
Int.J.Biochem.Cell Biol. 27, 1231-1248. Buxton,
I.L. (1996). HHMI awards [letter]. Science 271, 895 Kuenzli,
K.A., Bradley, M.E., and Buxton, I.L. (1996). Cyclic GMP-independent
effects of nitric oxide on guinea-pig uterine contractility.
Br.J.Pharmacol. 119, 737-743. Yang,
S., Buxton, I.L., Probert, C.B., Talbot, J.N., and Bradley, M.E. (1996).
Evidence for a discrete UTP receptor in cardiac endothelial cells.
Br.J.Pharmacol. 117, 1572-1578. Smith,
A.D., Cheek, D.J., Buxton, I.L., and Westfall, D.P. (1997). Competition of
adenine nucleotides for a 1,3-[3H]-dipropyl-8- cyclopentylxanthine binding
site in rat vas deferens. Clin.Exp.Pharmacol.Physiol. 24, 492-497. Bradley,
K.K., Buxton, I.L., Barber, J.E., McGaw, T., and Bradley, M.E. (1998).
Nitric oxide relaxes human myometrium by a cGMP-independent mechanism.
Am.J.Physiol. 275, C1668-C1673 Kuenzli,
K.A., Buxton, I.L., and Bradley, M.E. (1998). Nitric oxide regulation of
monkey myometrial contractility. Br.J.Pharmacol. 124, 63-68.
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