Kenneth W. Hunter, Jr.
The exquisite binding specificity of biological molecules such as antibodies has been exploited for the detection of numerous medically important analytes such as drugs, hormones, microbial toxins and toxic chemicals. The next generation of analytical technology will employ genetically engineered biological detector molecules interfaced with microelectronic devices. These new biosensors will revolutionize medicine by improving the speed and accuracy of biological measurements. Moreover, some biosensors will allow real-time, on-line analysis of biomolecules and feedback control of important physiological processes. However, there still remain many problems to overcome. Our research takes an interdisciplinary approach to these problems using state-of-the-art techniques in molecular biology, surface chemistry, solid state microelectronics, and microprocessor control.
Selected Publications
Hunter, K.W., A.A. Brimfield, A.T. Knower, J.T. Powell, and G.A. Feuerstein. 1990. Reversal of intracellular toxicity of the trichothecene mycotoxin T-2 with monoclonal antibody. J. Pharmacol. Exp. Therap. 255:1183-1187.
Hunter, K.W. 1989. Biosensors: A new analytical technology for real-time, on-line biochemical monitoring. Path. Patterns 91:32-33.
Mumma, R.O., and K.W. Hunter1988. Potential of immunoassays in monitoring pesticide residues in foods. In Pesticide Residues in Food: Technologies for Detection. U.S. Congress, Office of Technology Assessment, OTA-F-398, Washington, D.C.: U.S. Government Printing Office, pp. 171-181.
Newman, A.L., W.D. Stanbro, and K.W. Hunter. 1988. Development of an antibody-modulated planar capacitive sensor. In Proceedings of the First IEEE Conference on Synthetic Microstructures in Biological Research. M.C. Peckerar, S.A. Shamma, and R. J. Wyatt (eds.), pp. 45-49.
Hunter, K.W., and C. Peck. 1987. Technological advances in bedside monitoring: biosensors and transdermal dosimetry. Arch. Path. Lab. Med. 111:633-636.